percent_lymphocyte_infiltration tumor_nuclei_percent EBV pos East Asia percent_monocyte_infiltration year_of_initial_pathologic_diagnosis age_at_initial_pathologic_diagnosis RHOA:34_42 RHOA:57_62 MutSig2_rateTot_perMb MutSig_rateDbSnp_perMb Nonsilent Mutation Rate Silent Mutation Rate Total Mutation Rate absolute_extract_ploidy absolute_extract_purity days_to_birth percent_necrosis Number of Structural Rearrangments RNAseq MLH1_epigenetically_silenced diffuse_meth_subtype GEJUNC_CARDIA_EPC structural_rearrangement_count_WGS percent_neutrophil_infiltration M EPC APC:code_potential_somatic ARID1A:code_potential_somatic BCOR:code_potential_somatic CDH1:code_potential_somatic CYP7B1:code_potential_somatic ERBB3:code_potential_somatic FMN2:code_potential_somatic GLI3:code_potential_somatic KCNMB2:code_potential_somatic KIAA2022:code_potential_somatic percent_normal_cells MUC17:code_potential_somatic NRK:code_potential_somatic PIK3CA:code_potential_somatic PTEN:code_potential_somatic RHOA:code_potential_somatic RNF43:code_potential_somatic SLCO1B3:code_potential_somatic TLR4:code_potential_somatic TP53:code_potential_somatic PIK3CA:E545K PIK3CA:H1047R MSI-H MSI-L MSS Canada Germany South Korea Poland Russia Ukraine UNITED_STATES__country Vietnam FEMALE__gender MALE__gender ANTRUM__MAJOR_ANATOMIC_SITE_EPC FUNDUS_BODY__MAJOR_ANATOMIC_SITE_EPC GEJ_CARDIA__MAJOR_ANATOMIC_SITE_EPC Antrum vs. all other anatomic sites Antrum pyloris vs. all other anatomic sites Body vs. all other anatomic sites Cardia vs. all other anatomic sites Fundus vs. all other anatomic sites Fundus body vs. all other anatomic sites GE junction vs. all other anatomic sites pathologic M0 EPC M1__pathologic_M_epc N0__pathologic_N_epc N1__pathologic_N_epc N2__pathologic_N_epc N3__pathologic_N_epc GASTRIC-CIMP GASTRIC-EBV-CIMP Non-CIMP DNA Methylation EBV KB Subgroup MSI-H KB Subgroup SCNA High KB Subgroup SCNA Low KB Subgroup MicroRNA Cluster 1 MicroRNA Cluster 2 MicroRNA Cluster 3 MicroRNA Cluster 4 MicroRNA Cluster 5 TRUE__MLH1_methylation HIGH__SCNA_group LOW__SCNA_group Hypermutated Standard Mutation Rate Diffuse INTESTINAL__pathology_lauren Mixed lauren EARLY__STAGE_EARLY_LATE LATE__STAGE_EARLY_LATE Stage I vs. all other stages Stage II vs. all other stages Stage III vs. all other stages Stage IV vs. all other stages ASIAN__race RPPA Cluster 1 RPPA Cluster 2 RPPA Cluster 3 Gene Expression Cluster 1 Gene Expression Cluster 2 Gene Expression Cluster 3 Gene Expression Cluster 4 Mucinous vs. other intestinal Papillary vs. other intestinal Tubular vs. other intestinal percent_stromal_cells percent_tumor_cells percent_tumor_nuclei tumor_necrosis_percent A4B7_PATHWAY__9 0 -1.2 0.1 -0.4 0 -0.3 0.1 1.8 0 0 0 0 0 0 -0.5 -1.4 -0.1 -0.1 -2.1 -0.1 0.3 -0.3 -0.5 0 2.6 -0.3 0.2 0 0.3 0 0.5 -0.4 0 0 0 1.3 0 0.3 0.1 0.4 1.6 0 0 0 -1.8 0 0 0.3 -0.2 0 0 0 -0.1 0 0.4 0 0 0 0 0 0.3 0 -0.3 0.3 0 0 -0.2 0 -0.1 0 -1.9 2.6 -0.7 0 0 0 0.4 0.1 -0.4 0.1 0.3 -2.2 0.3 -0.1 -0.3 0.2 0.2 -0.2 0 -0.9 0.9 -0.1 -0.4 1.2 -1.2 0 -0.2 0.2 -0.3 0 0.4 2.3 0 0.4 0 0 0.3 1.4 -1.7 0.8 0.4 -0.8 0 0 -0.4 -0.7 -0.2 A6B1_A6B4_INTEGRIN_PATHWAY__46 0 0 -0.1 0 0.5 -0.2 2 0 -0.5 0.8 2 0.8 0.9 0.8 0.1 1.7 -1.9 0.6 0.3 1.9 -1.3 0 1.3 0.8 0 0.7 0.5 0.1 -3.1 0 0 0 1.9 1.2 -1 0.2 1.9 -0.2 -0.8 -0.7 0 0 0 0 0.1 0 -0.6 1.2 4.2 -3 0 0.7 0.2 0.1 -0.9 -0.1 0 -0.2 0 0 0.4 -0.5 0 0.2 0 0 -0.1 -0.1 0 1.6 0 0 0 0 1.5 0 1.7 -0.1 -0.7 -0.1 1.2 1 -0.9 -0.4 0.4 0.1 -0.7 -1.7 0.8 0.5 -0.5 1.2 -0.9 -1.9 1 1.1 0.3 -0.4 0.1 0 -0.6 0 0 -0.6 0 0.2 -0.9 -2 2.3 0.1 0 0 0 -0.1 0.2 1.1 2.8 AJDISS_2PATHWAY__48 0 0 -0.6 0 0 -0.1 1.9 0 -0.5 -1.2 -0.8 -1.1 -0.9 -1.2 0.1 0 -1.8 0.5 0.3 -1.1 -0.7 0 0.1 0 0 0 -1.6 -1.2 -1.3 0 0 -0.4 0 1.1 -0.9 0.2 -0.6 -0.2 -0.8 -0.6 0 0 0 0 0.1 0 -0.5 -1.3 1.4 0.7 0.4 0.6 0.2 0.1 0 -0.9 0.3 -1.5 0 0 0 -0.4 0 0 0 0 -0.1 -0.1 0 0.1 0 0 0 0 0 0 -1.5 -0.4 2.2 -0.6 -1.3 0.9 0.5 -0.3 0.8 -0.2 0.5 0.1 -0.7 1 -1 -0.8 1.1 -1.8 0.9 1 0 0 0.1 0 0 0 0 0.4 0 -0.4 0.7 -1.9 0.9 1.1 -0.4 0 0 -0.1 -0.3 0.1 1.4 ALK1PATHWAY__26 -0.4 0.6 -0.7 0.1 -0.4 -0.4 0 -0.3 0.1 -2.3 -2.1 -2.3 -2.5 -2.2 0 -1.4 0 -0.8 -0.1 -2 2 -0.6 0 -1.5 0.1 -0.5 -0.6 0 0.4 0.4 -0.1 0 -0.1 0.1 -1.2 0 -0.9 0 -0.3 -0.9 -0.1 0 -0.3 -0.1 -0.1 -3 0 -1.6 0 1.7 0 0 -0.8 0 0 0 -0.4 0 0 0 3.3 0 -0.6 3 0.9 -1.1 0 0 -0.1 -0.1 0 0.1 0.2 -0.8 0.1 -0.5 -0.8 -0.6 0.9 -0.7 -1.6 0 1.7 -1.3 -2.4 0 1.9 0 -1.2 0 0 -1.2 2.3 1.7 -1.8 0.1 -0.3 0.3 -0.4 0.1 0.8 0.1 0.2 2.2 -0.1 -2.1 2.2 -1.6 -0.2 -0.3 0.7 -1.7 0 1 -2.8 -1.4 -1.1 ALK1_2PATHWAY__3 0 0 0 0 0 0 0 0 0 -1.7 -0.5 -1.7 -1.9 -1.9 0 -0.5 0 -1.2 0 -0.8 0.4 0 0 0 0 -2.1 0 0 0 0 0 0 0 0 0 0 -2.1 0 0 0 0 0 0 0 1.4 0 0 -0.8 0 0.7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -0.8 0 0.7 0 -0.8 0 0.5 0 -0.5 0 0.4 0 -0.9 0 0 -1 0.7 0.5 -0.5 0 0 0 0 0 0 0 0 0.6 0 -0.6 0.3 0 -0.4 0 0 0 0 0 0 -0.7 0 ALK2PATHWAY__11 0.2 0 -1.1 1.2 0 0.1 0 0 0 -1.6 -1.9 -1.6 -1.8 -1.6 0.1 0.1 0 0 0.1 -2.1 0.7 -0.1 0.5 0 0 -0.1 -0.2 -0.4 0 0 -1.3 -0.1 0 0 -0.3 0 -3.6 -0.8 -2.1 -0.3 0 1.3 0 0 0.1 -0.8 0.2 -3 -0.1 1.8 0 -0.2 0 0 0.1 0 0 0 0 0 0.1 -1 -0.1 0.1 0 -0.3 -0.1 0 0 0 0 0 -0.3 0 1.9 0.8 -1.8 -1.1 2.2 -1.1 -2.8 0.9 0.2 0 -0.1 0 0.4 0 -2.2 -0.6 0.6 -2.4 2.9 0 -0.2 0 -0.1 0.1 -0.1 -0.3 0.2 0 1.4 0.2 0 -0.3 0.5 -2 0 0 0.2 -0.4 0 0.3 -0.2 0.1 -0.1 ALPHASYNUCLEIN_PATHWAY__33 -0.1 -1.2 -0.9 -0.1 -0.1 -0.9 0 0 0 -0.7 -1.1 -0.7 -0.8 -0.6 -0.2 -1.1 0 -1.1 1.3 -0.3 0.2 0.2 0.6 -0.8 -0.3 -0.1 -1.5 -0.5 1.1 0.1 0 -0.1 0 -0.1 -0.3 0 -0.2 0 -2.3 -0.2 0 -0.2 0 0.3 1.7 0.1 0 -0.7 0.1 0.7 -0.9 0.3 -1 0 0.1 0 -0.1 0 0 0 0 0 0.2 0 0.2 -0.4 0 0 0 0 0.2 -0.3 0 0.1 0 -0.1 -1.6 -0.7 2.7 -0.9 -0.7 1.4 0.3 0 -0.3 -1.1 0.2 0.7 -1.2 0.7 -0.7 -1.3 1.2 0.3 -0.1 -0.1 1.5 -1.5 -0.1 2.1 -1.9 -0.2 -0.5 0.1 0.2 -0.2 0.3 0.7 -0.7 0.6 0.1 0.4 -0.1 0.3 -0.1 -0.1 -1.4 AMB2_NEUTROPHILS_PATHWAY__41 -2.2 -3.7 0.1 -1.3 0 -1.7 -0.5 1.9 0 -1.1 -1.1 -1.7 -1.4 -1.2 -1.4 -4.3 0.5 -3.1 -1.9 -0.5 1.5 0 -3.7 0 -0.1 -0.9 -1 0.3 4.2 0 0 0 0.3 0 -0.1 0.9 -1.4 -0.8 0.4 -0.1 1.2 -0.1 0 0 -0.8 0 0.1 0.4 -0.6 0.3 0 0.1 -2.7 0 1.6 0.2 0 0.5 0.4 -0.4 0 -1.2 0 0 0.1 -1.6 0 -0.2 0 0 -1.7 -0.1 -0.2 -0.1 0 0.8 -0.4 0.1 0.8 0.1 0.4 -0.8 1.8 0 -2.8 0.5 1.6 0 0.3 -1.9 2 -0.8 0.7 2.4 -2.5 0 -0.6 0.6 -2.2 0 0 2.5 -2.5 2.1 0.1 -2.4 1.9 3.2 -4 0 3.7 -0.2 0 1.5 0 -2.2 -2 ANGIOPOIETINRECEPTOR_PATHWAY__50 0 -0.1 -1.2 -0.2 0 0 -0.1 0.6 0 -0.3 -0.3 -0.3 -0.4 -0.3 -0.3 -1.1 0.1 -0.1 -0.8 -0.3 1.7 -0.1 -0.3 0 1.3 -0.1 0 0 0.1 0 0 -0.2 0 0 -0.7 0.1 -0.4 -0.1 -0.6 -0.5 0.2 0 0 0 -0.7 -0.1 -0.4 0 0 0.2 -0.1 0 -1.4 -0.3 0.3 0 0.2 0.1 0 0 1.8 -0.3 -0.1 1.4 0 -0.6 -0.1 0 -0.2 0.1 -0.4 1.4 0 0 0 0.1 -0.1 -1 0.5 -1.2 0 0.2 0.7 -0.2 -1 -0.1 1.5 0 -0.1 -0.2 0.2 -0.2 0.1 1.5 -1.2 0 -1 1 -0.1 -0.9 0.3 1 -1 1 0 -1.1 1.5 -0.5 -0.5 -0.7 1.9 -1.1 0 0.5 -1.5 -0.9 -0.2 ANTHRAXPATHWAY__25 -0.7 0 0.2 0.3 0.1 -0.7 -0.1 0.2 0 0 0.1 0 0 0 0 -0.5 0.1 -0.2 -1.6 0.4 0.8 0 -1.4 0 0.3 0 0.4 0 0.8 -0.2 0 0.7 0 0 0.2 -0.5 0 -0.1 0.1 0 0.1 0.1 0 -0.2 -1.5 0.8 0 0.4 -0.8 -0.5 -2.2 0 0.9 -0.1 -0.3 -0.6 -0.8 0.1 0 0 1.2 -0.1 0 1.1 -0.5 0 0 -1.5 0.1 -0.2 -0.1 0.3 0.4 0 0.4 0 0.1 0.2 -0.4 0.2 0.4 -1.2 0.4 -0.3 -0.1 -0.1 0.4 0 0.3 -2.7 2.5 0.2 -0.5 0.4 -1 -0.7 0.1 -0.1 -0.8 0.2 -0.2 0.2 0.4 0.4 1.2 -0.2 0.6 0.2 -0.2 0.1 1.3 0 0.2 0 -1.1 -0.3 0.3 AP1_PATHWAY__70 0.2 -2 0 0.9 0 0.2 0.7 0 0 -0.1 -0.4 -0.2 -0.2 -0.1 -0.2 -1 -0.7 -2 -0.2 0 0.2 0.6 -1.4 0 0.1 -0.1 -0.9 0.1 1.6 0 0 -0.2 0.1 0 0 2.3 -0.3 -0.3 -0.2 -0.3 0 0 -0.4 0 -0.2 0 0 0 0 0.1 0 -0.2 -1.1 -0.7 0 0.7 0 3.3 0.1 -0.1 0.1 -0.8 0.6 0.1 -0.2 -3.1 0 0.1 -0.5 0.1 0 0.1 0.1 0.3 0.1 -0.7 -0.1 -0.1 0.1 0 0 0 0.9 0 -0.5 0.3 0.1 0 0 0 0 0 0.1 1.2 -1.9 0 0 0 -0.4 0 0 0 1.5 0.2 0 -0.2 0.2 0 -0.5 0 1.1 -1.1 -0.5 0 -0.1 -0.4 -0.9 ARF6DOWNSTREAMPATHWAY__15 -1.3 -0.3 -0.8 -0.1 0 -1.6 0 0.9 -0.7 1.6 1.2 1.6 0.9 1.6 -0.1 0 0 0.7 0 1.4 -0.9 0 0.2 0 0 0.1 0 0.2 -0.1 0 -0.9 1.7 0.2 0 0 0 -0.1 0 0 0.1 0 0.8 0 0 0 0 0.1 1.4 0 -1.6 0 0.1 0.1 -0.6 0.1 0.2 0 0 0.2 -0.2 0 -0.7 0 0 0 0 0 0 0 0.3 0 0 0 0 0 -2 1.7 -0.7 -1.4 -0.8 1.4 -0.3 -0.5 0 1 -0.5 -1.2 0 1.2 0.7 -0.7 1.1 -1.6 -0.1 0.2 1.1 0.6 -0.6 0.3 0.9 -0.7 0 -0.1 -0.4 -1.6 0.4 -0.5 0 0.1 0.3 -0.6 0 0 0 0.4 0.1 0 ARF6_PATHWAY__35 -0.1 0.1 -0.9 -0.1 1.9 -0.1 0 0 0 -0.7 -0.5 -0.7 -0.8 -0.6 -2 -0.5 0 -0.2 -0.3 -0.3 1.6 0.2 0.6 0.2 0 -1.4 -0.1 0 -1.2 0 0 -0.1 0 0 -0.3 1.5 -0.2 0 -0.8 -0.2 0 0 0 0 -0.3 0 0 -0.2 0.1 -0.2 0 -0.2 -0.2 0.7 0 0.5 0 0 0 0 0.1 0 0.2 0.1 0 -0.4 0 0 -0.4 0.8 0.2 0 -0.5 -0.2 0 -0.1 -0.2 -0.7 0.3 -0.9 -0.2 -0.2 1.8 -0.4 -0.3 -1.1 1.4 0.7 -0.1 -0.2 0.2 0.1 0.1 0.7 -0.8 2.8 0 0 -0.1 0 0.1 -0.2 0 1.1 0 -1.1 1.5 -0.7 -1.6 0.6 0.1 0.4 -0.1 0.3 -0.1 -1.2 -0.4 ARF6_TRAFFICKINGPATHWAY__49 0 0 -0.1 -2.4 0.4 0 -1.7 0 0 -2.8 -1.8 -2.5 -2.6 -2.8 -0.5 -2.5 1.6 -0.7 -0.2 -1.1 4.2 -0.2 0 0.7 1.6 -1.5 0 -1.2 0.1 0 0 -0.4 0.1 1.1 -0.9 0.2 -0.6 0.2 -0.8 -0.6 0 0 0 0 0 -0.1 -0.5 -1.3 -0.1 2.1 0.4 0.6 -1.6 0.1 -0.8 2.9 0.3 -3.8 0 0 0.3 -0.4 -0.2 0.2 0 -0.8 0.3 0 -0.4 0.1 -0.6 1.7 -1.2 0 0 3 -1.5 -0.1 1.6 -0.1 -1.3 -0.1 3 -0.3 -2.7 -1.8 3.7 -1.5 -0.7 -0.1 0.1 -1.5 1.7 2.3 -2.5 1 -1.2 1.2 -1.1 -1.1 0.5 1.2 -3.9 3.9 0 -3.5 3.6 -0.6 -1.8 -0.9 0.3 0 0 2.2 -1.7 -3.2 -2.1 ARF_3PATHWAY__19 -0.8 1.3 -0.3 0.4 -1 -2.6 0 -1 -0.2 0.3 0.1 0.3 0.1 0.3 0.7 0 0 0 1.8 -0.1 -1.6 1.2 2.3 -2.2 0 0 0 0 -1.1 0 -0.4 1 0.1 0.4 0.3 -0.7 0 0 0 0 -0.4 0.2 0 1.9 2.3 -0.1 0 -0.1 0.7 -0.1 0.1 0 0 2.6 -0.4 0 0.1 0 -1.3 1.3 -0.5 0.1 1.2 -0.4 0 0 0 -1.7 0.2 0.1 -0.2 0 0 0.9 0 -1.2 0 -0.2 0 -0.3 -0.1 2.1 -2 0.5 0.4 0 -1.4 1.9 -0.1 3.1 -3.2 0 0.1 -2 2.2 -1 0.2 -0.2 0.1 0.4 -0.3 0 0.6 -0.8 0 0.9 -1.5 0.1 0.2 2.1 -0.2 1.8 -1.2 -3.3 3.1 1.1 0 AR_NONGENOMIC_PATHWAY__31 0.2 0.2 -1.1 -0.2 -0.1 0 -1.1 -0.1 0 -1.4 -1.3 -0.8 -1 -1.4 -0.3 -0.2 1.1 -0.3 0 -1.2 0.7 0.2 0 0.3 -0.5 -0.1 -0.2 -0.7 0.1 0.1 0 -0.2 1 0 0 0 -0.3 0.1 -1 -0.4 0 -0.3 -0.1 0 0.7 0.1 0 -0.9 -0.1 1.8 0 -0.2 -1.2 0 0 0 0 0 0 0 0.2 0 0.2 0.1 0.3 -0.5 -0.1 0 1.6 0 0.3 -0.5 -0.7 0.1 0 -0.2 -1.8 -0.9 1.5 -1.1 -0.9 0.2 0.9 -0.6 -0.4 -1.2 1.2 0.8 -0.6 0.2 -0.2 -0.6 1.4 0.9 -0.5 -0.1 -0.1 0.1 -1.4 2.4 0.2 -0.3 -0.7 0.8 0 -0.8 1.1 -0.9 0.3 -0.1 0 0 0 0.5 -1.8 -0.1 -0.5 AR_PATHWAY__61 0.8 0 0 1.7 0 1.5 0.6 0 0 0.5 0.7 0.5 0.3 0.5 0.6 3.7 -0.5 2.1 0.3 0.6 -0.2 -0.6 0.3 0 0 1.1 0.5 -0.3 -0.3 0 0 0 -0.3 0.2 -0.1 0 0 1.9 -0.1 -0.1 -0.2 0.1 1.7 0 0.5 -1.2 0.1 -0.1 0 -0.2 0 -0.6 1.5 0 0 0.3 0 -0.4 0 0 -0.3 -1.7 -0.6 -0.2 0 0.3 -0.4 0.5 -1.5 0 2.1 0 0.4 0.9 -0.4 0 0.4 0 0.1 0 -0.1 0.2 -0.7 -1.4 1.5 0 0.5 0 0.4 0.3 -0.3 -0.1 0.1 -0.6 0.9 0.2 0 0 0.8 -0.2 -0.1 0 0.3 -0.7 -0.7 1.6 -0.5 -0.1 2.5 0.4 -0.1 0 0 -0.2 0 1.1 0.4 AR_TF_PATHWAY__53 1.8 0 -0.1 0 0.3 0.7 0.3 -2 0 -0.2 -0.2 -0.2 -0.3 -0.2 0.4 1.2 -0.3 0.3 0.8 -0.1 0.2 -0.1 0.9 2.8 0 -0.1 0.3 -0.9 0.1 -0.9 -0.5 0 0 0.8 0.4 2.1 0 -0.1 0 -0.4 -0.7 0 0 0 -0.7 -0.1 0.4 -0.5 0 0.5 0.2 -1.3 0.1 0 -0.6 0 0.2 0.1 0 0 0 0.1 -0.1 0.1 0 0 0.2 0 -1.2 -0.5 0 0 0 0 0 0 -0.6 -0.3 0.8 -0.1 -0.5 0.2 0.3 -0.1 0.6 -1.5 -0.1 0.1 0.1 0.3 -0.3 -0.5 0.4 -0.1 0.2 -2 0 0 1.6 -0.8 0.3 0 0 0.1 0 0.4 0.1 0 0.3 0.9 -0.2 3.4 0 -0.7 0.1 0.1 -0.2 ATF2_PATHWAY__59 0.1 -1.2 -2.3 0 0 -0.3 0.8 0 -0.1 0.2 0.1 0.2 0.2 0.2 0.1 -0.2 -0.7 0.6 0.1 0.1 0 1.5 -0.1 0.1 0.5 0.1 -0.7 0.5 0 0 0.1 0 0 0 0.1 1.5 -0.1 0 -1 -0.1 -0.3 0.1 0 0 0 0 -0.1 0 0 -0.1 0 0.1 -0.2 -0.1 0.1 -1.3 0 0 0 0 0 -0.1 1.4 0 0 -1.4 0.1 0 -0.6 0.7 -0.1 0.6 0.5 1.1 0 -1.8 0.1 -1.9 0.4 -2.2 0 0.3 -0.2 0 0.2 0.2 -0.1 0 0.1 0.1 -0.1 0.1 -0.1 -0.1 0.1 0 0.1 -0.1 0 -0.3 -0.1 0.3 0 -0.1 0 0 -0.1 -0.9 0.2 0 0.9 0 0 0 -0.1 0 0.5 ATM_PATHWAY__34 1.8 0.1 0.2 1.7 0 0.3 2.2 0 -1.9 4 3.8 4.3 4 4.3 4.4 4.3 -2.1 4.3 2.4 2.6 -4.3 -1.8 0.5 0.1 -0.3 4 3.4 0.5 -2.9 0.1 0.1 0.1 0 -0.1 4.3 0 1.5 3.7 0.7 1.4 -2.7 0 0.1 0.3 4.3 0.1 2.3 2.1 0 -1.8 -0.8 0 4 -1.6 0 -0.8 -0.1 0 4.2 -3.9 0.1 1 -1.8 1.4 0 3 -1.5 0 -1.8 0 0.2 -0.3 0 4 -3.2 -0.1 2.7 0.2 -3.6 0.2 2 2.1 -4.3 -1.8 4.3 2.8 -4.3 0 2.2 2.2 -2.2 1.9 -2.4 -4.3 4 0 1.4 -1.4 0.9 -0.4 0 -0.2 2.2 -4.3 0.2 4.4 -4.4 0 4.3 -0.8 0 0 0 -2.7 1 4 0.3 ATR_PATHWAY__39 0 0.1 1.7 1.3 0 -0.6 4.3 0 -4.3 4.4 4.4 4.4 4.4 4.4 4.4 4.3 -4.3 4.3 1.9 4.3 -4.4 -1.1 2.1 0 -0.1 4.4 4.3 4.3 -4.3 0 3.9 3.5 0.3 0 4.3 0 4.3 4.4 3.6 4.3 -4.3 1.8 3.8 4.3 4.3 0 1.7 4.3 0 -4.3 0 0.1 4.3 0 0 -4.3 0 -0.8 0.4 -0.4 0 4.3 -1.1 0 0 4.3 -3.8 0 -1.2 0 0.1 -0.1 0 3.6 -4.3 0 4.3 1.7 -4.3 1.6 4.3 0.9 -4.4 0 4.3 3.8 -4.4 0 4.3 1.8 -1.8 4.3 -4.3 -4.4 4.4 -3.5 3.7 -4 3.4 0 -1.4 -0.1 1.8 -4.4 0 4.4 -4.4 0.1 4.4 0 -1.1 0 2.1 -4.3 4.3 4.4 3.8 AURORA_A_PATHWAY__31 0 0.2 1.3 2 0 0 2.8 -0.1 -2.4 4.3 4.3 4.3 4.4 4.3 4.4 2.1 -2.6 3.6 2.6 1.1 -4.3 -0.1 0.8 0.3 -0.5 2.5 0.7 0.8 -3.7 0.1 0.2 0.1 1 -0.2 2.2 0 1.9 1.9 1 1.9 -3 -0.3 0.2 0.5 4.4 0.1 0.4 1.1 0.1 -2.2 -1.1 -0.2 3.1 0 0 -1.2 -0.1 -0.1 1.2 -1.2 -2.8 4.3 -0.1 0 0 3.5 -0.1 0 0 0 0.3 -0.5 3.1 0.1 -3.5 -0.2 1.5 1.3 -3.1 1.3 1.1 1.6 -4.4 0 4.2 1.3 -4.4 0 0.8 1.7 -1.6 1.5 -1.4 -4.4 4.4 -0.1 4.3 -4.3 1.2 2.4 -2.1 -0.3 0.1 -4.4 0.3 4.4 -4.4 0 4.4 -0.1 -1.9 0 3.3 -4.3 1.3 3.1 0.6 AURORA_B_PATHWAY__41 0 0 0 3.6 0 -0.4 4.3 0 -4.3 4.3 4.3 4.3 4.3 4.3 4.3 4.3 -4.3 4.3 4.3 4.3 -4.3 -3.2 1.9 0 -0.1 4.3 3.8 4.3 -4.3 0 3.9 3 0.2 0 4.3 0 4.3 4.3 1.1 4.3 -4.3 1.4 3.8 4.3 4.3 0 1.4 4.3 0 -4.3 0 0.1 4.3 -0.9 1.3 -4.3 -3 0 3.1 -3 0 4.3 -3.2 0 -3.4 4.3 -3.3 0.2 -0.1 0 0.1 -0.1 0 0 -4.3 0 4.3 0 -4.3 0 4.3 1.5 -4.3 -0.1 4.3 0.3 -4.3 0 4.3 2.5 -2.4 4.2 -4.3 -4.3 4.3 -3.4 3.5 -3.5 3 0 -4.3 -0.1 1.6 -4.3 0.1 4.3 -4.3 0 4.3 0 -0.9 0.1 0 -4.3 3.1 4.3 3.6 AURORA_C_PATHWAY__5 0 0 0 2.7 0 1.1 0 0 0 1.3 1.5 1.2 2.4 1.2 1.1 0 0 0.7 1 -0.6 -1.3 0 0 0 0 0 1.1 2.2 0 0 0 0 0 0 0 0 0 0 0.8 0 0 0 0 0 1.1 0 0 -2.3 0 -0.5 0 0 1.4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -0.6 0 -0.3 0 -2.1 0.8 -1.5 0 0.3 1.4 -2.1 0 -0.6 0.8 -0.9 -0.7 0.5 -1.9 0.4 0 0 0 0 0 0 0 3.2 -2.6 0 0.7 -2.1 0.6 1.9 0 0 0 0 -1.4 0 0 0 AURORA_KINASE_PATHWAY__3 0 0 0 0 0 0 0 0 0 1.6 0.5 1.6 1.7 1.6 3.7 0 -1.5 1 1.4 0 -1.8 0 2.3 0 0 0 0 0 -1.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.4 0 0 0 0 0 0 0 1.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -0.5 0 0 1.1 -3.4 0 0.6 0 -2.6 0 0 1.1 -1.1 0 0 -2.4 2.5 0 0 0 0 0 0 0 0 -3 0 1 -2.6 0.8 2.3 0 0 0 0 -1.8 0 1.7 0 AVB3_INTEGRIN_PATHWAY__75 0.1 -0.1 -1.1 0 -0.1 0.3 -0.9 -0.1 2 -3.6 -2.9 -3.3 -3.6 -3.1 -0.1 -2.1 0.8 -1.4 0.4 -2.9 3.6 0.3 -0.1 0.1 0 -2.8 -1.4 -1.8 3.6 0.2 0 -0.8 -1.4 0 -3.6 0.1 -2 -3.6 -1.3 -2.4 0.3 -0.6 -0.1 0 -0.1 -1.8 -0.4 -2.8 0 2.3 0.5 -0.5 -3.7 0 0.1 1.5 -0.2 3.6 0 0 2.1 -2.3 0.3 0.3 0.9 -3.6 0 0 0 0 -0.7 0 -0.4 0 0 0.1 -2.3 -0.3 1.7 -1.1 -2.5 0.2 3.1 -0.8 -3.6 -0.1 3.7 -1.4 -1.9 0.3 -0.3 -2.6 3 3.6 -3.1 0 -1.1 1 -3.3 0 0.9 0 -0.4 3.6 0 -3.7 3.7 -0.3 -0.3 -3.6 3.7 -3.6 -0.2 2.5 -3.6 -3.6 -3.3 AVB3_OPN_PATHWAY__31 -0.1 -1.4 -0.2 -0.2 -0.1 -0.1 0 -0.1 0 0.1 -0.1 -0.1 0 0.1 -0.3 0 0 -0.3 -0.4 0 0.3 0.2 -0.3 0 0 0.4 0 0 0.1 0.1 0.2 0 0 -0.2 -0.5 0 0 0.1 0 0.2 0 0 -0.1 0 -0.4 0.1 0.4 0.1 0 0 0 0.4 -0.3 0 0.2 -1.2 -0.1 -0.1 0 0 0.2 0 0.2 0.1 0.3 0 -0.1 -0.6 -0.6 1 0 0 0 -0.3 0 -0.2 0.2 -0.2 0 -0.2 0.1 -0.2 0.5 0 0 0.1 0.5 0 0 -0.3 0.3 0.1 -0.2 0.1 -0.5 -0.1 -0.1 0.1 -0.1 -0.6 0 0 0.1 0.1 0.3 -0.3 0.3 0 -0.1 0 0.2 0 -0.2 0.5 -0.2 -0.7 0 BARD1PATHWAY__29 0.3 0.3 1.6 2.2 2.4 0 4.3 -0.1 -4.4 4.4 4.4 4.4 4.4 4.4 4.4 4.4 -4 4.4 2.9 4.3 -4.4 -0.2 1 0.5 -0.6 4.4 4.4 3.5 -4.4 0.2 2.9 0.2 -0.1 -0.2 2.6 -0.1 4 4.4 3.6 4.4 -3.4 3.3 0.3 0.6 2.2 0.2 3.1 4 0 -4 0 0 4.4 0 0.4 -3.7 -0.2 -2 1.5 -1.5 -0.1 1.6 -0.2 0 -0.1 3.9 -2.4 0 -2.7 0 0.5 -0.6 0.1 0.1 -3.7 -0.3 4.4 1.5 -4.4 1.6 4.3 0.9 -4.4 0 4.4 3.9 -4.4 -0.1 4.3 1.9 -1.8 4.3 -4.3 -4.4 4.4 -0.1 2 -2 4.3 -0.8 -2.5 -0.5 2.8 -4.4 0 4.4 -4.4 0.1 4.4 0 0 0 0 -4.3 1.6 4.4 2.4 BCR_5PATHWAY__67 0 -2.3 -0.1 0.1 0 0.1 0 1.8 0.1 0 0 0 0 0 -1.7 -1.6 0 -1.5 -3.1 0 0 0 -0.4 0 0.1 0 0 0 0.6 -2.4 0.4 -0.3 0.2 0 0 -0.2 0 0 0.5 0.2 1 1.6 0 0 -1 0 0.6 0.1 -3.5 0 0 -0.2 0 0.1 -0.1 0 0 0.3 0.2 -0.2 0.2 0 0 1.1 0 0 0 0 -0.7 -1.8 0 0.1 0.1 0 0.1 0 0 0.3 0 -0.1 0.1 -2.5 0.3 -0.7 -0.1 0 0 0 0 -2.5 2.4 0.1 0 0.5 -0.6 -0.6 0 0 -0.6 -0.1 0 0 0.1 0 0 0 0 2.3 -3.2 0.1 0.2 -0.1 0 0 0 -0.5 0 BETACATENIN_DEG_PATHWAY__18 2.2 1.7 0 0.6 0.4 2.1 0 0 0 0 0 0 0 0 1 0.9 0 0.4 0 0.1 0 -2.4 0.1 2.8 -2.3 0.1 0 -0.1 0 0 -0.6 0 0.1 0 0.5 -1 0 0 0 -0.1 0 0.4 0 0 0 -0.2 0 0 0 -0.2 0.3 -1.8 0 -0.3 -0.6 0.1 -1.4 0.2 -1.6 1.6 -0.7 0.2 -2.4 -0.7 0 0.1 0 0.1 0.3 -0.5 2 -2.3 0.9 1.2 -0.9 0 0 0 0 0 0 -0.1 0 -0.9 0.6 -0.3 0 0 0.1 0.4 -0.5 0.1 0 -0.5 0.1 0 0.3 -0.3 0.2 -0.1 0 -2.1 0.8 0 0 0.2 0 -1.1 1.2 0 -0.4 0 0.7 0 0.2 0 0 BETACATENIN_NUC_PATHWAY__80 0.1 0 -0.2 0 -0.2 0.2 -0.1 -0.2 -0.7 -0.2 -0.2 -0.1 -0.1 -0.2 1.2 0.3 0.1 0.7 0.7 -0.3 0.4 0 0.7 0 0 0.2 -0.6 -0.6 0.3 0.4 -0.9 -0.1 0.1 0 0 0.3 -0.2 -0.2 -0.7 -0.2 0 0 0.6 0 0.4 0.3 0 -0.4 0.1 0.4 0 -0.7 -0.3 0 0 0.5 -0.3 0.1 -0.6 0.6 0 0.1 0 0 1.2 -1.2 0 0 0 0 0.9 0 1.7 0.2 0 -0.5 -0.5 -0.6 1.1 -0.2 -0.4 1.3 0.4 0 0.7 -0.2 0.1 -0.3 -0.2 1.4 -1.4 -0.6 0.2 -0.2 0.2 0 0.4 -0.4 1.4 -0.6 0 -1 0.1 -0.3 -0.1 0.5 0.2 -0.1 1.4 -0.9 0.1 0 -0.4 1.2 -0.7 0.3 -1.4 BMPPATHWAY__42 1 4.2 -2.2 0 1 1.5 -0.4 0 0 -2.5 -1.5 -2.6 -2.4 -2.6 0 -0.4 0.4 -1.4 0.1 -1 4.2 -0.8 0 0 -0.1 -0.7 -2.5 -2.1 0.4 0 0 -1.2 0 0 -1.7 3.4 -1.1 -3.3 -1.4 -3.3 0 -0.1 0 0 -0.1 -0.6 -1.1 -2.1 0 1.4 -0.4 -0.8 -2.4 0 0 4.2 0 0.4 -0.1 0.1 3 -1 -0.8 2.8 0.1 -4.3 0.6 0.2 -1 0 0.1 -0.1 -0.1 0 0 0.6 -2.3 -2.9 3.9 -2.2 -2.1 0.8 2.1 -2.5 -2.5 -2.4 4.3 0.4 -1.3 0.3 -0.3 -2.3 2.5 1 -1.1 1.8 -2.2 2.2 -1.9 -2.2 4.2 -0.1 -0.1 3.5 -3.2 -3.2 3.6 -4.3 0 -0.3 1 -0.1 0 1.3 -2.8 -1.1 -4.3 BOTULINUMTOXINPATHWAY__9 0 0 -1.6 0 0 0.2 -1 -3.5 0 -1.2 -0.4 -1.1 -1.3 -1.1 0 0.1 1 -0.1 1.9 -1 1 0 0.8 0 0 -0.3 -3.4 -0.7 0.3 0 0 -0.4 0 2.2 0 1.3 -0.5 0 -2.5 -0.5 -2.1 0 0 0 0.2 -1.3 0 -0.9 -0.2 0.9 0 0 -0.1 0 0 0.8 0 1 0 0 0 0 0 0 0 -0.6 0 0 -0.1 0 0 0 0 0 0 0 -0.9 -1.5 2.7 -1.6 -0.8 2.6 0.3 -0.1 -0.3 -1.1 2 3.2 -1.1 1.2 -1.3 -1.2 2 0.3 -0.4 0 -0.2 0.2 1 -0.7 0.4 0 0 1.2 0 -1.5 0.8 -2.4 -0.2 0 0.4 0 -2.9 0.6 -0.4 0 -1.9 CASPASE_PATHWAY__58 1 -1.2 3.4 0.2 2.1 0.9 0.8 0.1 -0.1 2.9 4.1 3.1 3.5 2.9 0.1 1.6 -0.7 0.1 -2.1 4.1 -4 0 -0.1 1.7 0 1.3 4 2.2 -1.6 0 3.5 1.3 3.3 -1.6 2.2 -0.7 4 0.6 4.1 2.3 0 0.1 2 0 -0.3 1.4 3.7 4 -0.3 -3.2 0 0.1 3.1 -0.1 -0.3 -0.2 0 -0.5 0 0 0 1.1 0 0 0 0.4 -0.6 0 -0.1 0.7 0 0 0.5 0 -0.5 0 4 2.6 -4.1 3.7 4 -2.7 -2.2 0 1.7 3.1 -2.1 -2.2 4 -2.1 2 4.1 -4.1 -1.9 1.7 0.3 1.6 -1.6 0.9 0.2 -0.1 0 0.4 -2.2 2.2 1.8 -4 1.7 0.6 0.5 -1.9 0 0.3 -1.4 0 0.4 0.5 CD40_PATHWAY__31 0 0 1.4 -0.2 0 0 0 0 0 -0.2 -0.3 -0.1 -0.1 -0.2 -0.3 -0.8 0 -0.3 -0.5 -0.1 0 -0.1 -0.3 0 0 -0.2 0 0 -0.1 -3.9 0.3 -0.3 0 -0.2 0 -0.1 0 0.2 1.1 0 0 0 -0.1 0.5 -0.5 0.1 0.4 0.2 -1.7 0.3 0 0.5 0 0 0 -0.1 0 -0.1 0 0 0 0 -0.1 0.1 0 0 0 0 0 0 0 0 0.1 -0.3 0 0 -0.1 1.4 0 1.4 0.2 -1.7 0.2 0 -0.2 0.1 0 -0.1 0.2 -1.2 1.2 0 -0.1 0.2 -0.2 -0.1 0 0 -0.1 0 0 0 -0.8 0 0 -0.1 0 2.5 -2 0 0 0 -0.2 0 0 -0.8 0 CD8TCRDOWNSTREAMPATHWAY__69 0 -4 4.1 -0.1 0 0 0 3.2 0 0 0 0 0 0 -0.1 -2.4 0 -1.8 -4.1 0.1 0 0 -4.1 0 0 0 0.1 0.6 0.4 -3.8 1.4 -0.1 0.8 -4.1 0.1 0 0 0.7 4.1 0.8 2.3 0 0 -0.3 -2 1.6 1.6 0.7 -4.1 0 0.1 -0.1 0 -0.1 3.6 0 0 0 1 -1 -0.4 1.2 0 0 -1.2 0 0 0.8 1.5 -3.1 0 0 0 0 0 0 0 4.1 -0.7 4.1 0.8 -4.1 0 2.8 0 0.3 0 0 0.2 -4.1 4.1 1.6 -0.6 0.1 0 0 0 0 -0.4 0.2 0 0 0 0 0 0 0 4.1 -4.1 0 0 -0.5 0.3 0 0 -0.1 0 CD8TCRPATHWAY__53 0 -4.1 4.2 -0.1 -1.7 -0.1 -0.1 3.8 1 -0.1 -0.1 -0.1 -0.1 -0.1 -1.6 -4.1 0 -1.2 -4.1 -0.2 0 -0.1 -3.6 0 0 -0.1 -0.1 0.8 2.2 -4.1 0.2 -1.8 0 -4.2 0 0.1 0 0.1 4.2 0.1 2.9 0 0 -0.6 -2.4 0 0.3 -0.4 -4.1 0.9 0.1 0.3 0 -0.1 2 0 0.1 0 0 0 0 0 0 -0.6 0 0 0 0 0.1 -3.3 -0.2 0 -0.7 0 0.9 0.1 -0.5 4.2 -0.3 4.2 -0.4 -4.2 0.2 3.1 -0.2 0.5 0 0 -0.9 -4.1 4.1 -0.1 0.1 0.4 -0.5 0 -0.7 0.7 -0.7 0 0.2 0 0 0 0 0 0 4.2 -4.2 0 0.1 -0.8 0.6 0.4 -0.1 -1.2 0 CDC42_PATHWAY__70 0.2 0 -0.9 0.9 0.8 0 0.1 -0.4 0 0.1 0.3 0.1 0.1 0.1 0.1 1.4 -0.1 0.4 0.3 0.4 -0.7 -1.2 0.9 0.4 0 0 0 0 -0.5 0 0.2 0.4 1.5 0 0 -0.1 0 0 0 0 0 0 0 0 0.6 -0.3 0.4 0.2 0.1 -0.2 1.1 0 1.6 0.1 -1.3 -1.2 0.7 -0.7 -0.8 0.8 1.2 0 -1.2 0.8 0 0 -2.6 0.1 -1.5 1.3 0 0 0.1 0.3 0.1 0 0.5 -0.8 0 -1 0.2 0.2 -0.3 -1.4 1.5 0 -0.2 -0.6 0.2 0.2 -0.2 0.1 -0.2 -1.1 0.6 0 0 0 0.2 -0.9 0 0 1.5 -0.2 0 0.3 -0.5 -0.8 0.5 0.1 -0.7 0 0 -1.3 0.3 0.4 0.1 CDC42_REG_PATHWAY__30 2.7 0.3 0 0.1 2.6 1.8 0 -0.1 0.1 -0.6 -0.5 -0.6 -0.8 -0.6 0.1 -0.1 0 -0.5 0.1 -0.6 1.1 -0.2 1.1 3.7 0 -0.3 -0.4 -1.1 0.2 0 0 -0.4 -0.1 0 -0.8 -0.1 -0.6 0 -0.1 -0.6 0 -0.5 -0.1 0 0.1 0 0 -1.2 -0.1 1.3 0 -0.4 -0.5 0 -0.1 0 2.6 0 -0.4 0.4 0.4 0 -0.2 0.2 0 -0.7 -0.2 0 0 0 0.5 0 0.1 0 -0.1 0 -0.5 0 0.6 0 -1.2 0.3 1.3 -0.9 -0.7 0 0.8 0 -0.8 1.1 -1.1 -0.9 1 0.7 -1.4 0 -0.1 0.1 -0.2 0 0.5 -0.5 0.1 1.2 -0.1 -1.1 1.4 -1.2 0.5 -1.5 0.4 0 0 -0.1 -0.4 -0.3 -2.1 CERAMIDE_PATHWAY__48 0 -0.1 0.1 0 0.4 -0.1 0 0.7 -0.4 0.6 0.8 0.6 0.7 0.7 0 1.4 0 0.5 0 0.8 -1.1 -0.1 0 0.6 0 0.5 1.4 0 -0.1 0 0.4 2.3 1.6 0 0.5 -1.5 0.2 0.1 0.4 0.2 0 0 0 0 0 -0.1 0.6 1 -0.1 -1 0.3 0.6 1.1 1.3 -0.7 -0.8 0 -1.4 0 0 0 0.1 -0.1 0 0 0 -0.1 -0.1 -0.3 0.1 0 0 0 0 0 0 1.4 0 -1 0.1 0.9 0 -0.1 -0.2 1.3 0.9 -0.2 0.1 1.3 -0.1 0.1 1 -0.7 -0.5 0.3 0 0.3 -0.3 0.1 0.7 0 0 0 -0.4 0 0.1 -1 0 0.1 1 -0.3 0 0 -0.1 0.1 0.1 1.3 CIRCADIANPATHWAY__16 0 0 0 0.7 0.5 0.9 0 -1.7 -0.5 0.7 0.3 0.7 0.8 0.7 1.2 1.1 0 0.6 0.9 0.2 -0.7 1.6 0.2 0 0 0.1 0 0.2 -1.8 -0.9 0 0 0 0 -0.1 0 0 0 0 -0.1 -0.8 0 -1.7 0 1.1 -0.3 0.1 0 1.1 -0.2 0.5 0.1 0 -0.5 -0.8 0.2 0.4 0 -1.8 1.8 -0.9 0.3 1.6 -0.8 0 -0.1 3 0.1 0 0.2 0 0 0 1.4 -1.1 0 0 0 0 0 0 0.5 -1.9 0 0.8 -0.4 -1 0 0.1 0.5 -0.6 0 0 -1.6 3.1 -1.6 0.4 -0.4 0.2 -0.1 0 0 0.9 -1.3 0 1.4 -1.6 0 2.5 0.2 -0.5 0 0 -1.7 0.3 1.6 1.1 CONE_PATHWAY__23 -0.9 1.5 -0.4 0.5 -1.2 0.6 -0.2 -1.2 0.8 -1.3 -1.8 -1.3 -1.5 -1.3 0 -0.3 0.2 0 0.6 -2.1 0.6 1.3 0.1 0 0.7 0 -1.6 -2.8 0 0 -0.5 0 -0.7 0.5 0 0.2 0 -0.2 -1 0 0 0 -1.2 -0.5 0 -0.1 -0.3 -1.8 0 1.8 0.2 0 -1.8 0 -0.5 0.1 0.2 0.2 0.1 -0.1 0 -0.3 1.3 0 0 -0.1 2.7 0 -0.7 0.1 -0.3 0.8 0 -1.9 0.7 0.1 -1.8 -0.3 1.9 -0.4 -1.7 1.3 0.2 -0.7 -0.7 -0.2 0.7 2 -2.2 0.3 -0.4 -2.3 2.5 0 -0.2 0.5 0 0 -1.3 0.5 0 0.5 0.7 0.7 -0.9 -0.4 0.6 0.1 -0.4 0.1 0 0 0 0.1 0 -0.1 -0.6 CXCR4_PATHWAY__102 -0.6 -1.5 1.4 -2.9 -1 -0.3 -0.1 3.2 0.3 -0.1 -0.1 -0.1 -0.1 -0.1 -2.9 -2.9 0.1 -0.2 -3.2 0 0.6 -1.3 -3.2 0 0.2 0 0.4 0 3.1 -0.1 0.6 -1.9 -0.2 0 0 0 0 0.2 1.9 0.2 2.7 0 0 -2.1 -2.6 -0.2 0.1 0.2 -3.2 0.1 0 0 -1.1 0 3.2 0 0 -0.8 0 0 -0.1 1.5 -1.3 0.1 0.1 0 -0.9 0 0.4 -1.4 -1.3 0.3 -2 0 0.2 0.3 0 1.4 -0.2 1.4 0.2 -3.2 0.6 0.1 -0.8 0.3 0.9 -0.6 0 -3.2 3.2 0.3 -0.2 1.8 -1.4 0 -1.8 1.5 -2.2 0.1 0.6 0.1 -1.8 0.8 0 -0.9 0.7 3.2 -3.2 0 0.3 -0.4 0 0.8 -1.1 -2 0 DELTANP63PATHWAY__47 0.4 -0.1 -0.6 0.7 0.5 -0.2 -0.2 -2.7 -0.5 0.2 0.2 0.2 0.2 0.2 1.6 0.5 0.1 0.1 2.1 0 -0.8 2.4 1.3 0 0 0 -0.3 0.1 -1.4 0 0 0 0.1 0 0 0 0.3 -0.2 -0.8 -0.7 -1.1 0 0 0 1.5 -0.2 0 -0.1 0 -0.1 -0.2 0 1.4 0 -0.9 -0.1 0 0.2 0 0 0 -0.5 2.4 0.2 0 0 0.3 -0.1 -0.4 0.1 0 0 0 0 0 0 -0.1 -0.5 0.3 -0.7 -0.1 1.7 -0.9 0 0.1 1.1 -0.7 -0.1 0 1.8 -1.8 0 0.1 -1.3 1 0 0.3 -0.4 -0.2 0.8 0 0 1.1 -0.1 0 0.2 -0.9 -0.7 1.6 0.1 0 0 0 -1.1 0.2 0.2 0.4 DNAPK_PATHWAY__16 0 0 0 0.7 0.5 -1.4 1.3 -1.7 -0.5 1.4 1 1.4 0.8 1.4 1.2 1.1 -1.3 4.2 0 0.2 -1.5 0 0.2 0 0 2.6 0 0.2 0 1.8 0 0 0 0 0.6 0 0 0 0 0.1 -0.8 0.6 0 0 1.1 -0.3 0.1 0 0 -0.2 0 2.5 1.8 -0.5 -0.8 0 -1.6 0 0.1 -0.1 0 -0.5 0 0 -1.5 0.1 0 0 0 0 0 0 0 0 -1.1 0 0.5 0 -0.4 0 0 0 -1 -1.1 1.9 0 -1 0 0.1 0 0 0.1 0 -0.7 1.9 -1.6 0.4 -0.4 0.2 0 -0.6 0 0.9 -1.3 0 1.4 -1.6 0 2.5 0 -0.5 0 0.8 0 0.3 1.6 0 E2F_PATHWAY__74 0.1 0 1 0.7 0 0.2 3.7 -0.2 -3.7 3.8 3.8 3.8 3.8 3.8 3.8 3.8 -3.7 3.7 2.1 3.8 -3.8 -0.8 0.7 0.2 0 3.8 3.7 3.7 -3.7 0.4 3 3.2 0.1 0 3.8 -0.1 3.7 3.7 3.2 3.7 -3.7 1 3.4 1.3 3.7 0.3 1.5 3.7 0.1 -3.8 0.7 0 3.8 -0.5 0 -3.2 0 0 0.1 -0.1 0 3.4 -0.8 0 -0.1 3.8 -2.2 1.4 -0.3 0 0 0 1.7 0.2 -3.8 0 3.8 1.1 -3.8 1 3.7 0.3 -3.8 0 3.8 1.1 -3.8 0 3.7 0.4 -0.4 3.7 -3.7 -3.8 3.8 -0.2 2.1 -2.2 1.4 1 -0.7 0 1.2 -3.8 -0.1 3.8 -3.8 0 3.8 -0.2 -0.5 0 1.4 -3.8 3.7 3.7 3 ECADHERIN_1_PATHWAY__3 0 0 0 0 0 0 1.7 0 0 0.4 0.5 0.4 0.4 0.4 0 1.4 -1.5 1 1.4 0 -1.8 0 0 0 0 0 0 0 -1.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -0.8 0 0 0 0 0 0 0 -2.2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.5 0 -0.5 0 0 0 -0.5 0 2.6 0 -0.7 0 0 0 0 0 0 -2.4 2.5 0 0 0 0 0 0 0 0 -0.9 0 1 -1.3 0 2.3 0 -3.6 0 0 -1.8 0 0 1.5 ECADHERIN_KERATINOCYTE_PATHWAY__21 0 1 0.2 0.3 0.1 0 0.4 0.2 -0.1 0 0.1 0 0 0 0.5 0.4 -0.4 0 0.3 0.4 -0.6 0 0 1.9 0 0 0 0 -0.8 0 0 0 -0.3 0 0 0.1 0 -0.1 0 0 0.1 -1.3 0 0 0.5 0.8 -0.1 -0.4 0.5 0 0.1 0 -0.2 -0.1 -0.3 0 0.1 0.1 -1.1 1.1 -0.3 0.1 0 -0.3 0 0 -1.1 0 0.1 2.4 0 0 0.4 0 -0.4 0 -0.5 0.2 -0.1 0.2 -0.4 0.9 -0.9 -0.3 0.2 0 -0.3 -0.9 -0.1 0.9 -0.9 -0.1 -0.1 -1.6 0.9 0.2 0.1 -0.1 0 0 -0.2 0 0 -0.1 0 0.1 -0.7 0 1.3 1.8 -0.1 1.5 0.2 -0.7 0.1 0 0.3 ECADHERIN_NASCENTAJ_PATHWAY__39 0 0.1 0.1 0 1.2 0.1 1.5 0 0 0.1 0.7 0.1 0.2 0.1 0.3 1.2 -0.2 0.4 -0.8 0.4 0.6 0 0.3 1.9 -0.1 0.1 0.2 -0.2 -0.7 0 0 0 0.3 0 0 0.9 1 0 0.4 1 0 -0.1 0.1 0.1 -0.8 0 1.7 0.4 0 -0.5 0 -1 0.7 -1.1 0 0 0 0 0.4 -0.4 1.1 -1.2 0 0.8 0.1 0 -0.9 -0.2 -1.2 0.4 0 -0.1 -0.2 -0.1 0 0 0.7 0.1 -0.9 0.1 0.4 -1.6 -0.7 -1.2 0.5 0.5 -0.2 -0.7 0.9 -1.1 1.1 0.6 -0.6 -1.5 0.6 0 0 0 0 -0.1 0 -0.1 0 0 0 0 -0.3 -1.5 1.9 -0.5 0 0.2 0 -0.5 0.6 0 0.1 ECADHERIN_STABILIZATION_PATHWAY__42 0 0 0 0 0.8 0.5 1 1.3 0 -0.1 0.2 -0.1 -0.2 -0.1 0.2 0.8 -1 0.2 0.6 0.2 1 0 0.1 1.3 -0.1 -0.5 0.1 -1.8 -1.9 0 0 0 0.1 0 0 0.5 0 0 -0.2 0 0.7 0 0 0 0.1 0 0 0.1 2 -0.2 0.9 1.1 0.4 0.1 -1.2 -0.2 0.7 -0.4 0 0 0.7 -0.8 0 0.5 0 0.1 -0.4 -0.1 -0.1 2 0 -0.1 -0.1 0 2 0 0.4 -0.2 -0.2 0 0.1 1.3 -0.4 -2.2 1.4 0 1.2 -2.5 0.1 0.7 -0.7 0.1 -0.1 -1.7 0.8 1.6 -0.3 0.3 0.3 -0.1 1 0 -0.1 0.8 0 -0.4 0.8 -2.5 0.9 1.5 0 0.1 0 -1.6 -0.6 -0.1 2 ENDOTHELINPATHWAY__63 0.6 -0.7 -1.7 -0.6 0 0.2 -2.2 0.1 0.3 -2.5 -2.2 -2.3 -2.5 -2.3 -0.7 -1.8 2.2 -1.1 -0.1 -1 2.1 0 -0.7 0 0.2 -1.5 -0.4 -1.7 1.1 -0.2 -0.1 -0.7 0.4 3.1 -1.3 1 -2.2 -0.9 -1.7 -0.9 0 0 -1 -0.1 -0.6 -1 0 -1.2 -0.1 2.6 0 -0.5 -1.9 0.3 -0.1 1.4 0 0.6 0 0 0.5 0 0 0.3 0 -2.4 0 0 0 0.4 0 0.3 -0.1 0 0.3 1 -1.9 -2.3 2.7 -1.7 -1.1 -0.3 2.2 0 -2 -2.2 3 0 -0.8 -0.4 0.4 -1.6 2 1.6 -1.8 0.1 -1.2 1.2 -2.4 0.1 0.8 0.1 -0.1 3.1 0 -2.8 2.7 -1.5 -1.1 1.3 2.1 -0.2 -1.1 2.2 -1.8 -2.3 -1.6 EPHA2_FWDPATHWAY__19 0 -0.1 0 0.4 0 -1 0.7 0.3 -0.2 0.3 0.6 0.3 0.4 0.3 0.7 0.6 -0.6 0.2 1.8 0.1 -1.6 0 2.3 0 0 0 0 0 -3.5 0 0 0 0.1 0.4 0 -0.7 0 0 0 0 -0.4 0.2 0 0 2.3 0 -0.2 0.1 0.7 -0.8 0.1 0 0 -0.2 -0.4 -0.9 0.1 0 0 0 0 0.1 0 0 0 0 -1.5 0 0 2.8 0 0 0 0 0 -1.2 0.2 0 -0.1 0 0.1 2.1 -2 0.5 1.2 -0.2 -0.5 -1.3 0.1 3.1 -3.2 0.4 -0.2 -3 3.2 -1 0.2 -0.2 0.1 0 -0.3 0 0.6 -0.8 1.5 0.9 -1.5 -0.8 1.7 0.1 -0.2 1.8 0 -3.3 3.1 1.1 0.6 EPHA_FWDPATHWAY__34 0.2 -1.3 0.3 -0.1 -0.1 0.4 0 -0.1 0 -1.3 -1.2 -1.3 -0.9 -1.2 0.7 -2.4 0 -1.2 0.5 -1.1 0.6 0.2 2.8 0.2 0 -0.1 -0.2 -0.6 1.2 0 0 -0.1 0 -0.1 -0.4 0 -0.3 0 0.2 -0.3 0 0 0 0.4 -0.3 0.1 0 -0.8 0.1 1.6 0 0.3 -1.1 0 0.2 0.6 -0.1 0 -0.2 0.2 0.1 -2 0.2 0.1 0.3 -0.4 0 0.9 0 0.9 0 0 -0.6 -0.2 0 1.6 -0.9 0.3 0.1 0.3 -0.8 -0.7 0.8 0 -2 0 1.5 0 -1.3 0.8 -0.8 0.5 0.6 0.8 -0.9 -0.1 -1.3 1.4 -1.2 0 0.2 0 -0.6 1.2 0.3 -1.2 0.9 1.7 -2.8 0 0.2 -0.7 -0.1 0.4 -0.1 -1.3 0.5 EPHBFWDPATHWAY__40 0 0 -0.3 0 1 0.1 0 0 0 -0.5 -0.4 -0.5 -0.3 -0.5 0 0.1 0 0 0.1 -0.4 0.2 -0.8 0.2 1.6 -0.1 0.1 0 -0.1 -0.5 0 -1.3 0 0.2 0 -0.1 0 -0.1 -0.6 -1.4 -1.3 0 -0.1 0 0.1 0.2 -0.6 0 -0.7 0 0.2 -0.4 0 0 0.2 -1.5 0.2 0 0.4 0.2 -0.2 3 -1 -0.8 2.8 0.1 -0.1 -0.6 0.2 -1 0.3 0.1 -0.1 -2.2 0 0 0 -0.3 -1 0.7 -0.3 -0.7 0.8 -0.1 -2.5 0.1 0 0 -0.4 -0.5 0.9 -0.8 -0.6 0.6 -0.1 0.1 0 0.8 -0.8 0.4 -0.1 1.2 -0.1 -0.1 0 0.1 0 0 -1.3 0.2 0.3 0 0.1 0 0 0.5 0 -0.1 EPHRINAREVPATHWAY__3 0 0 0 0 0 0 0 0 0 -0.7 -0.8 -0.8 -0.8 -0.8 0 -0.8 0 0 0 -1.2 0.7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1.1 0 1.1 0 0 0 0 0 0 0 0 0 0 0 -3.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1.2 0 1 0 -1.1 0 0.8 0 -0.8 0 0.7 0 -1.3 0 0 -1.3 1.1 0.8 -0.8 0 0 0 0 0 0 0 0 0.9 0 -1 0.5 0 -0.7 0 0 0 0 0 0 -1 0 EPHRINA_EPHAPATHWAY__8 0 0 0 0 0 0.6 -1.7 0 0 -3 -2.4 -3.1 -3.3 -3.2 -1.2 -1 1.7 -0.4 -0.5 -1.8 3.3 0 0 0 0 -0.9 -0.9 0 0.8 0 0 -1.2 0 0 -1.4 2.3 -1.1 0 -0.7 -1.2 0 0 0 0 -0.4 -2.3 0 -1.6 0 1.6 0 0 -3 0 0 1.4 0 0 0 0 1 -2.1 0 0.9 0 -1.2 0 0 0 1.6 0 0 -1.6 0 0 0 -1.7 0 1.2 0 -1.5 0 3.2 0 -2.9 -1.7 4.1 0 -1.9 0 0 -2.1 1.5 2 -2.1 3.4 -0.8 0.8 -0.8 0 1.2 0 0 3.8 0 -4 3.7 0 -0.7 -0.7 1 0 0 1.2 -1 -1.6 -2.8 EPHRINBREVPATHWAY__30 -0.2 0 0 -0.2 -0.1 0 0 0 0 -0.9 -1.4 -0.5 -0.6 -0.9 0.1 -1.4 0 0 1.6 -1.3 0.1 0.3 0.9 0 0 0 -0.2 0 -0.1 0 0 -0.3 0 0 -0.6 -0.1 -0.4 -1.7 -0.1 0 0 0 0 0 -0.5 0.1 0 -1.7 0.1 1 0 0 -0.3 0 0.3 -0.1 0 0 -0.3 0.3 0 0 0.3 0.1 0.4 0 1.2 0 0 0 0 0 -0.8 -0.3 0 0 -1.1 -0.2 1.6 0 -1.7 1.7 0.5 0 -0.5 0 0.1 0 -1.5 1.8 -1.7 -1.6 1.6 0.2 -0.2 -0.1 -0.1 0.1 -0.1 0 0 0 0 0 0.4 -0.1 0.2 0.5 -1 -0.1 0 0.6 0 -0.1 1.4 -0.8 0 EPHRINB_EPHBPATHWAY__6 0 0 -0.4 0 0 0 0 0 0 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GLYPICAN_2PATHWAY__2 0 0 1.6 0 0 0 0 0 0 0 0 0 0 0 1.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.6 0 0 -0.8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.4 0 0 0 0 0 0 0 0 0 0 0 GLYPICAN_3PATHWAY__8 0 0 -0.2 -0.6 0 0 0 0 0 -1.4 -1.7 -1.4 -1.5 -1.4 0 -0.6 0 0 0.3 -1.2 0.4 0 0 0 0 0 -0.5 0 0.4 0 -1.9 0 0 0 0 0 -0.7 -1.5 -0.4 -0.7 0 0 0 0 0 0 0 -1.1 0 1.1 2.2 0 -0.2 1 0.6 -0.3 0 0 0 0 0 0 0 0 0 -0.8 0 0 1.5 0 0 0 -1 0 0 0 -1.1 -1.7 1.9 -0.2 -1 0.2 0.5 -0.2 -0.5 0 0.8 0 -1.4 0.2 -0.2 -1.5 2.3 0.5 -0.5 0 -0.3 0.3 -0.4 0 0.6 0 -1 0.5 0 -0.7 1 -0.3 -0.4 1 0.6 0 0 0.8 -0.6 0 -0.2 GMCSF_PATHWAY__37 -0.1 -0.8 0.1 -1.6 0 -0.7 0.3 0 0 0.2 0.2 0.2 0.2 0.2 -0.1 -0.1 -0.3 -0.1 -0.1 0.5 -0.2 0 -0.1 -0.6 0 0 0.3 0.4 0 0 1.8 0 0.5 -0.1 0 0 0 1.2 0.6 0.1 0 2 0.1 0 -0.1 0 0.1 0.6 -0.8 -0.1 0 0.1 0 0 1.9 -0.6 0 -1 0.6 -0.6 0.1 0 0 0 0 0.3 0 0.5 -0.2 0 0 0 -0.3 -0.1 0 -0.1 0.3 0.1 -0.6 0.1 0.6 -1 0.2 -0.2 -0.1 0 -0.1 0 0.4 -1.4 1.3 0.8 -0.8 0.2 -0.2 0 -0.8 0.8 0 -0.2 -1.6 0 -0.3 0 0.1 0 -0.1 1.3 -0.2 0 0 -0.3 0 0 -0.1 -0.3 0.2 HDAC_CLASSIII_PATHWAY__40 0.1 0.1 -0.6 3.7 0 2 -0.7 0 0 0.1 0.2 0.1 0.2 0.1 0.4 0 0.6 0 0.2 0.1 -0.2 0.1 0.4 -0.6 -0.2 0.1 -0.1 -0.3 0 0 -1.7 0 0 -0.1 1.6 -3 -0.1 0 -0.5 -0.1 0 -0.1 0.1 0.2 2.6 0 0 -0.5 0 0 -0.7 -2.8 0 0.5 -4.3 0 0 0.7 -0.1 0.1 0 0.8 0.1 0 0.1 0 0 -0.3 1.1 0 0.1 -0.2 2.4 0 0 -0.1 -0.1 -0.5 0.5 -0.6 -0.5 1.9 0 0 0 -0.8 -0.3 0.5 -0.2 1.2 -1.1 0 0.1 0 0 0 3.8 -4 0 4.3 -1.6 -0.1 2 -0.2 0.1 0 -0.1 -0.4 0.1 0.5 -1.3 0 2.4 0 0 0 0 HDAC_CLASSII_PATHWAY__34 0.1 0.1 0.2 1.7 -0.1 1.1 -0.8 0 0 -2.6 -3 -2.2 -2.5 -2.9 0.5 -0.9 0.8 -1 1.2 -1.7 0.9 0 -0.1 0.1 -0.3 -1.3 0.5 0.5 -0.1 0.1 0 -0.1 0 -0.1 1.8 0 -0.2 0.1 -0.7 -0.2 0 -0.2 0.1 0 1.6 -1.3 -1.9 -1.3 0 2.2 -0.8 -1.4 1.1 0.6 0 0.4 -0.1 0 -0.2 0.2 0 1 0 0 0.2 0.4 0 0 1.3 0 0.2 -0.3 2.7 0 -3.2 1.4 -2.4 0.2 1.2 0.2 -1.3 0.6 1.7 0 -2.3 0.9 -1.2 0 -2 0.6 -0.6 -1.2 1.9 1.7 -2.5 0 1.4 -1.4 -1 0 -1.8 -0.2 0 -1.7 0 1.9 1.4 0.1 -1.9 -0.8 0.1 0 0 0.3 -0.1 -1.1 -0.3 HDAC_CLASSI_PATHWAY__66 1.9 1.1 0.1 4 1.3 3.3 0 0 0 0.5 1.1 0.5 0.5 0.5 1 3.1 0 0.2 0.6 0.3 -1.1 -0.2 0.2 0.8 0 0.7 0.2 0.2 -0.9 0 -0.1 0.7 2.1 -0.9 1.4 -0.3 0.3 0 0 0.3 -0.1 0 1.3 -0.1 0.9 0.8 0 0.5 0.3 -0.4 -3.9 -1.4 3.4 1.6 -1.9 0.1 0 0.4 -1.1 1.2 -0.1 0.5 -0.2 -0.1 0 0.1 -1.5 0.2 -0.2 0.3 0 0 2.5 0.6 -2.7 0 0.5 0.1 -0.9 0.1 0.5 0.4 -0.7 -0.1 1 0.7 -1.3 0 0.5 0.5 -0.5 0.3 -0.8 -0.7 1 0.1 0.9 -0.9 0.4 -0.1 -1.4 0 4 -1.4 -0.3 1.8 -1.6 0 1.8 -0.1 -1.2 0 0.1 -0.1 0.5 1.9 0.2 HEDGEHOG_2PATHWAY__22 0 0.9 -0.1 0 -0.6 0.2 -2.4 -0.6 0.3 -4.3 -4 -4.3 -4.3 -4.3 0 -3 2.3 -2.8 0.3 -3.9 3.6 0.8 0 0 0.2 -3.2 -3.2 0 3 -0.2 -0.2 -1.4 -0.3 0.1 -1.7 0 -4.2 -3.1 -2.1 -4.2 0.1 -1.1 -0.6 0 -0.2 0 -0.1 -2.9 0 3.2 0 -1 -4.4 0 0 1.7 -0.7 2.3 -0.9 0.9 -0.3 -0.1 0.8 -0.2 1.3 -4.4 0 0 0.1 -0.1 -0.1 0.3 0 0 -0.3 0 -3.2 -0.1 3.9 -0.1 -3.2 0.1 4.3 0.2 -4.3 -2.4 3.6 1.6 -2.6 0.1 -0.1 -3.8 3.9 3.9 -4.2 0.2 -0.6 0.6 -2.7 0.2 1.3 0.1 0 3.2 -0.3 -4.3 4.3 0 -0.9 -2.5 1.1 0 0 1.4 -3.4 -3.1 -4 HEDGEHOG_GLIPATHWAY__48 2 3 -0.1 2.8 0.4 2.5 -1.6 0 -0.4 -2 -1.7 -1.9 -1.8 -2.1 0.1 1.4 1.6 -0.1 0 -1 1.8 0 0 0.6 0 -0.2 -0.2 -1.1 1.1 0 -0.7 -0.3 0 0 0 0.2 -0.5 0.1 -0.7 -0.5 -0.9 0 0 0 0 -0.1 0.6 -1.2 -0.1 2 0.3 -1.5 -1.5 -0.3 -0.7 1 0 1.6 0 0 0.3 -0.4 0 0.1 0 -0.7 0.2 0 -0.3 0 0 0 0 0 -1.2 0.1 -2.1 -0.1 2 -0.1 -1.2 0.1 1.8 -1.4 -1.1 -0.2 1.6 0.1 -0.6 0.1 -0.1 -1.4 1.6 1.1 -0.8 0 -0.1 0.1 -0.1 0 0.4 0 0.9 1.6 -1.9 -1.2 2.2 -0.6 0.4 -0.8 0 0 0 0.6 -1.6 -0.4 -2 HES_HEYPATHWAY__48 0.4 -0.1 0.2 0.7 0.4 2.7 -0.1 0 0 -0.2 0.2 -0.2 -0.2 -0.1 0.6 1.5 0.1 0 0 -0.1 0 -0.2 0.1 0.7 0 -0.2 0 0 -0.1 -1.2 0 0 0.1 1.1 0 0.2 0 0.2 0.1 0 0 0 0 0 0.1 -0.1 0 -0.1 -0.1 0 0.4 -1.6 1.2 0.1 0 1.1 0 -0.1 0 0 0 0.1 -0.2 0 0 0 0.3 2 -0.4 0 0 0 1.3 0 -1.3 0.2 -0.3 0 0.3 0.2 -0.1 0 0.1 0 -0.4 -0.2 0.1 0.1 0.2 0 0 -0.2 0.2 -0.2 0.1 0 0.3 -0.3 2 0 0 0 1 -0.5 0 0.6 -0.2 0 0.5 0.1 -0.4 0 0 -0.1 0 -0.1 -0.3 HIF1APATHWAY__19 -0.8 0 0 3.4 0 -1 -0.1 -1 -0.2 0.8 1.3 0.8 0.9 0.8 0.7 2.5 0.1 0.2 0.5 0.7 -0.3 -1.7 0.1 -2.2 0 1.9 0.6 0.1 0 1.2 0 1 -0.5 -1.1 0.3 -0.7 0 0 0 1.4 -0.4 0.2 1.4 0 2.3 1.1 -0.2 0.6 0 -0.1 -2.5 -1.4 1.1 -0.2 -0.4 -0.9 -1.1 0.1 0 0 -0.5 0.1 -1.8 -0.4 0 0 0 0 0.2 -0.3 0 0 0 0.9 -0.6 -1.2 0.2 0.4 -0.7 0 0.7 0.2 -0.6 0.5 0.4 0 -0.5 1.9 0.1 0.3 -0.3 0.4 -0.8 0 0 -1 0.2 -0.2 0 4.3 -0.3 -1.7 4.4 -0.8 0 0.9 -0.2 0 0.2 0 -0.2 0 -1.2 0 0 3.1 0 HIF1_TFPATHWAY__66 -2.5 0 -3.9 -3.6 -3.5 -3.3 1.2 0 0 0.5 -0.4 0.5 -0.4 0.5 0 -0.1 -1.1 1.5 0.1 -0.4 0 0 0.2 0 0.1 0.7 -1.4 1.5 0.1 -0.1 -0.1 0.7 -0.2 0.1 0 0.8 -0.6 0 -1.4 0.3 0 0 1.3 0 0 0.8 0 0.5 0.3 -0.9 0 2 -0.3 0 0.6 -1.8 0 -1.2 0.3 -0.3 -2.1 0.5 0 -1.9 0 3.4 0 0 0 0.3 -1.9 0.2 -0.1 0 0.2 0 -0.3 -3.6 1.9 -3.6 0.5 0.4 0.1 0.1 0.5 -2 -0.1 0 -0.2 0 0 0.3 -0.4 0.1 -0.1 0.1 -0.1 0.1 -0.1 -0.1 0 0.1 -3.6 -0.4 1.5 0.2 -0.1 -0.4 0.2 0.2 0.4 0 -0.9 0 0 -0.1 2.8 HIF2PATHWAY__34 0.1 0 0 -0.1 -0.1 -2.2 0.6 0 0 0.1 0.1 0.1 0.2 0.1 0 0.5 -0.5 2.1 0.4 -0.3 -0.1 0.2 0.6 -0.8 0 0.3 -0.1 0.6 -0.1 0 0 0 0 -0.1 -0.3 0 -0.2 0 0 0.1 0 0 0.1 0.3 0 0.1 0 -0.2 0.1 -0.2 -0.9 0.3 -0.2 0 0 0 0 -0.1 0 0 0 1.1 0.2 0 0.2 3.2 0 0 0 0.8 0 0 0 -0.2 0 -0.1 0 -0.1 0.1 0 -0.2 0.1 -0.3 0 0.3 0 -0.6 0 -0.4 0.1 -0.1 -0.1 0.1 -0.8 0.4 -0.1 0 0 -0.1 0 0.1 0 -0.5 -0.3 0.2 0.4 -0.3 0 0.6 0.6 0.1 0.4 -0.1 0 0 1 0.4 HIVNEFPATHWAY__36 0.1 -0.9 2 0 0 -0.8 0.4 0 0 1.9 2.3 1.9 2.1 2 -0.1 1.6 -0.4 0.7 -2.4 3.5 -1.7 0.1 -1.8 0 -0.2 1.9 3.3 0.5 0 0 2 0.1 0.6 -0.1 1.7 0 1.3 1.3 4.3 1.3 1.6 2.1 0.1 0.2 -1 0 4.3 3.2 -1 -1.6 0 0.2 1 0 0.1 -0.7 -0.1 -1.1 0.7 -0.7 0 0 0.1 0 0 0.4 0 0.6 -0.3 0 0.2 -0.2 0 -0.1 0 -0.1 3.3 2.1 -4 2 3.5 -3.5 -1 0 2.5 0.8 -0.4 -1.1 3 -3.5 3.4 2.8 -3 -1.2 1.5 0 0 0 0.8 0 0 -0.1 0 -0.8 0.2 0.9 -2.3 2.6 -0.5 0.5 0 0.3 0 0 0 0.8 1.4 HNF3APATHWAY__44 1 0 0 1.1 1 4.3 -2.5 0 0 -1.4 -0.9 -1.4 -1.2 -1.5 0.2 0 2.4 -1.4 0.7 -1 0.4 2.9 0 1.6 -0.1 -0.7 -0.8 -0.1 0.4 0 -1.3 0 0.2 0 -0.1 0 -0.1 -0.6 -0.3 -1.3 0 -0.1 0 0 0 0 -1.1 -2.1 0 1.4 -0.4 -2.4 0 0.2 -1.5 1.8 0.9 0.4 -0.1 0.1 -1.7 0 3.1 -1.6 0.1 -1.4 4.3 0.2 -0.1 0.3 0.1 -0.1 0 0 0 0.6 -2.3 -0.3 1.8 0 -2.1 1.5 1 1.5 -0.6 -0.5 0.2 3.8 -1.3 0.9 -0.8 -1.4 1.8 0.2 -0.3 0 0 0 0 0 0 -0.1 -0.1 1 0.1 -1.5 0.5 -0.2 -0.1 4.3 0 0.1 0 0.1 0.5 -0.1 -1.8 HNF3BPATHWAY__45 0.8 0 -1 0 0 0 0.1 0 0 -1.2 -0.7 -1.2 -0.9 -1.2 0.9 0.8 -0.1 0 2.6 -1.6 -0.8 2.8 1.7 1.3 -0.1 0 -0.6 -1.8 0 0 -4.3 0 0 1.8 0 0 -2.7 -0.4 -1.2 -1.1 0 0 0 0.1 0.8 0 -0.9 -2.6 0 1.2 0 0 0 0.1 0 0.1 0 -0.4 0 0 -1.5 0 2.9 -1.4 0 -0.1 0.5 -0.1 0 0.2 0 -0.1 -0.1 0 0 0 -2.1 -1.7 2.2 -1 -2.5 3.8 -0.2 0 2.1 -4.3 -0.1 3.8 -1.9 4.3 -3.8 -2.1 2.2 -2.4 2.1 0 0 0 0.3 -0.1 0 0 0 -0.3 0 0.1 -0.6 -1.1 0.1 4.3 -0.8 4.3 0 -3.3 2.9 0 0.1 HNF3PATHWAY__3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.5 0 0 0 1.4 0 -1.8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -0.8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.5 0 0 0 -0.8 1.1 -0.5 0 0 0 -0.7 4.3 0 1.1 -1.1 0 0 -0.6 0.7 0 0 0 0 0 0 0 0 -0.9 0 0 -1.3 0 0 2.1 0 0 0 -1.8 2.9 0 0 IFNGPATHWAY__43 0 0 1.2 0 0 0.1 0 0 0 0.1 0 0.1 0 0.1 0 0 0 0 -0.4 0.1 0.1 -0.5 -0.8 0 -0.1 0 0.8 0.1 0 0 0 0 0.1 0 0.9 0 0 0.4 1.8 0 0 0 0 -1.7 0 0 0 0.5 -0.2 0 -0.3 0 0 -0.7 0.9 0 0 -2 0.1 -0.1 -1.4 0.3 -0.5 -1.3 0 0.1 -0.3 0.1 -0.7 -1.2 0 0 -0.1 0 0 0.4 0.1 1.2 -0.5 1.1 0.5 -1.1 0 -0.6 0 0.2 0 -2.3 0.4 -1.3 1.4 0.8 -0.7 0 0 0 -0.2 0.2 0 -1.6 0 0 0 0 0 0 0 1.2 0 -0.2 0 0 0 0 -0.6 0 0.6 IGF1_PATHWAY__30 0.3 0 -0.3 0.1 0 -0.1 0 -0.1 0 -0.2 0.5 -0.1 -0.2 -0.2 0.1 0.8 0 0 0.6 -0.5 -0.2 0.3 0 0.4 -0.6 0 -0.2 0 -0.1 0 0 -0.3 1.1 -0.2 -0.6 -0.1 0.2 0 -1.1 -0.4 0 -0.3 0.3 0 0.8 -1.9 0 0.6 0.1 -0.1 0 -0.3 0 0 0 0 -0.2 0 -0.3 0.3 0.2 0 0.3 0.1 0.4 -0.6 -0.1 0 -0.7 1.1 0.4 -0.6 0.1 0.1 0 -0.2 -0.1 -1 0.5 -0.3 0.6 0.9 0 -0.7 0.1 0 0.1 0.9 0.2 0.9 -0.9 0.2 -0.3 -0.1 0.2 -0.1 -0.1 0.1 0 -0.7 0.3 -0.4 0.1 -0.5 0 0.1 -0.3 -1 0.9 -0.1 -2.1 0 0 -0.1 -0.2 0.1 0 IL12_STAT4PATHWAY__33 -0.1 -1.4 4.4 -2.5 -0.1 -1.1 0 3 0 0.1 0 0.1 0 0.1 -2.3 -4.3 0 -0.3 -4.4 0.3 0 -0.1 -4.3 0 0 0 0.7 3 1.4 -3.9 2.6 -0.2 1 -3.9 0 0 0.2 0.1 4.4 0.2 2.2 0 0 -3.9 -4.3 0.1 2.7 1.1 -4.3 0 0 0.4 0 -1.9 4.3 0 -0.1 -0.1 1.2 -1.2 0 0 -0.1 0.1 0 0 0 1.1 0 -3 0 0 0 -0.3 0 0 0.2 4.4 -2.4 4.4 1.1 -4.4 0 2.6 0 1.3 0 0 0.8 -4.4 4.4 2.4 -1.4 0.1 -0.2 0 -0.1 0.1 -0.1 0 0 0 -0.7 0 0.3 0 0 4.4 -4.4 0 0.2 -0.8 -0.2 0 0 -0.7 0 IL1PATHWAY__34 -0.1 0.2 0.3 -0.1 0 -1 0 -0.1 0 0.2 -0.2 0.2 -0.1 0.2 0 0 0 0.1 0 0.2 -0.4 0.2 -0.2 0 -0.4 -0.1 0 0 -0.1 0 0.2 -0.1 0 0 -0.4 0 0.1 0.1 0.2 0 0 -0.2 0 0 -0.3 0.1 0.3 0.1 0.1 -0.3 0 2.2 0.1 0.8 0.2 -1.1 -0.1 -1.5 -0.2 0.2 0.1 0 0.2 0.1 0 0.6 0 -0.5 -0.5 0 0.3 -0.4 -0.6 0 3.6 0 -0.3 0 -0.1 0.3 0.1 0 0 0 0.1 0 -0.2 0 0.2 0 0 0.1 0 0 0 -0.1 0 0 0 -0.5 0.2 -0.3 0 -0.1 0.3 0.1 -0.2 0 0 0.7 0 0.4 -0.1 -0.1 -0.1 0.1 3.6 IL27PATHWAY__26 -0.3 0 4.4 -0.6 -0.3 -0.3 0 0 0.1 0 0 0 0 0 -0.7 -2.9 0 -0.7 -2.3 0 0 0 -3.1 -1.4 0 -0.4 0.1 1.4 0.3 -4.3 0.7 -0.7 0 -0.4 0 -0.1 0.5 0 4.4 0 3.4 -0.6 0 0 -3.6 0.3 0.9 0.1 -4.3 0 0 0 -0.1 0 0.7 0 -0.3 -0.3 0 0 -0.1 0 0 -0.1 -0.1 0 0 0 0 0 0 0 0 -0.7 0.1 0 0 4.4 -1.8 4.4 0.1 -3.7 0 0.1 -0.4 2.1 0 -0.2 0.1 -3.8 3.6 0.4 -0.1 0.4 -0.4 0.1 -0.2 0.2 -0.3 0 0.7 0 0 0 0.7 -0.1 0 4.5 -4.3 -0.2 0 -1.5 0.1 0 0 -1.3 0.1 IL2_PI3KPATHWAY__37 0 0 1.8 0 0 0 0 0 0 0.2 0.4 0.2 0.2 0.2 0.4 1.3 0 -0.1 -0.9 0.5 -0.1 -1.3 -1.5 0.1 -0.2 0.1 0.3 0.3 0 0 0.1 0 0.4 0 0 0 0 0 1.4 0.1 0 -0.1 0.1 0 -0.9 0 0.1 0.5 -0.7 -0.1 1.6 0 0.8 -1.2 0 0 0 -0.9 0.5 -0.5 0 0.7 -1.3 1 0 0.2 -1 0.4 -0.2 0 0 -0.2 -0.2 0 0 -0.1 0.3 1.8 -1 1.8 0.5 -2.5 -0.4 -0.1 0.6 0.6 -0.1 -0.8 0.3 -2 2.1 0.7 -0.7 -0.1 0.2 0 0 0 0 -0.2 0 -0.1 0 -0.6 0 0.2 -0.3 1.7 -0.4 0 0 0 0 0 0 0 0 IL2_STAT5PATHWAY__30 0 0 4 -0.3 -0.2 -0.2 0 0 0.1 0.1 0 0.1 0.1 0.1 -0.4 -1.6 0 -0.4 -3.6 0.1 0 -2.8 -2.7 0 0 -0.2 0.1 1 1.7 -3.9 2.9 -0.3 -0.1 -0.2 0 0 0.3 0.2 4.3 0.3 2.8 0 0.3 0 -1.8 0.2 0.5 0.2 -1.9 -0.1 0 0 0 0 0.4 -0.1 0 -0.2 0 0 -0.1 0 -2.8 0.2 -0.1 0 -0.1 1.4 0 -3.5 0 0 0 0 0 0 0 4 -1.4 4 0.2 -4.4 0.2 0.1 -0.1 0.1 0.2 -2.1 0.3 -4 4 0.8 -0.3 0.6 -0.7 -0.1 -0.1 0.1 -0.2 -0.8 0.4 0 0 0 0 0 0 4.4 -2.6 -0.1 0 -1 0 0.6 -0.3 -0.9 0 IL3_PATHWAY__27 -0.4 0 0.1 -0.7 -0.4 -1.8 1.7 0.1 0.1 -0.4 0.5 -0.4 0.3 -0.4 0.2 -0.7 -1.6 0.6 0.1 -0.2 -0.7 0.6 -0.8 0 0.1 0 0.1 0 -0.4 -0.1 0.8 0 0 -0.5 0.1 -0.2 0 0 0.6 0 -0.1 0 0 0 0.2 0.4 0 -0.2 0.2 -0.2 0 1 -0.1 0 -0.1 -0.2 0 -0.4 -0.7 0.7 -0.1 0 0.6 -0.1 -0.2 0 -0.4 -1.1 0 -0.1 0 0.1 0.2 0.3 0.1 -0.5 0.2 0.1 -0.6 0.1 -0.2 -0.7 -1.1 0.1 -0.5 0.3 -0.6 -0.3 -0.3 -0.9 0.8 0.5 -0.2 1.1 -0.5 -0.4 -0.3 0.3 0 0.1 0.8 0.1 0.2 -0.3 0.8 0.3 -1.1 0.4 0.8 0 0 0 0.1 -0.3 0 -0.5 1.3 IL4_2PATHWAY__65 0 -0.7 1.2 -0.6 -0.9 0 0 0.1 0.3 -0.1 -0.1 -0.1 -0.1 -0.1 -0.7 -3.7 0 -2 -1.5 0 0.1 0 -2.3 0 0.2 -0.3 -0.4 0 2.6 -3.2 0 0 -0.2 0.1 -0.1 0 -0.1 0 0.8 -0.9 4 0 -1 -0.1 -0.6 0 0 0 -3.1 0.3 0 0 -0.4 0 0 0 0 0.6 0 0 0.5 0 0 0.3 0 -0.1 0 0 0 -0.1 0 0.3 -0.1 0 0.3 1 -0.1 1.3 0 1.2 0 -1.8 0.9 2.1 -1.5 0.1 0.1 -0.1 -0.1 -1.6 1.5 0 0 1.6 -1.4 -0.9 -0.1 0.1 -1 0.1 0.8 0.1 -0.1 0.2 0 -0.6 0.3 4 -4 -0.1 2.1 -0.2 -1.1 0.1 0 -2.7 0 IL5_PATHWAY__14 0 -0.3 0.9 -0.1 0 -0.1 0 0 1.4 -0.1 -0.1 0.3 -0.1 -0.1 -0.1 -0.6 0 0 -1 0.3 0.4 0 -2.9 0 1.4 -0.1 1.3 0.2 0 -1.2 0.1 0 -1.2 0 0 0 -0.1 0 2.2 -0.1 0.6 0.8 0 0 -1 0 0.1 0.5 0 0.3 0 0.1 0 0 0.1 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0.1 -0.1 0 0.2 -0.3 -0.7 0.1 0 -0.1 0.1 0.1 -0.1 0.8 0 0 0 0 -0.2 -0.7 -0.5 NETRIN_PATHWAY__32 -0.1 0.2 -0.9 -0.1 0 -0.1 0 -0.1 0 -1.3 -1.2 -1.3 -1.5 -1.2 -0.2 -0.2 0 -0.2 0 -1.1 0.6 0.2 -0.2 -0.9 0 -0.1 -0.2 -0.6 -0.1 0.1 0 -0.1 0 0 -0.4 0 -0.3 0 -0.1 -0.3 0 -0.2 0 0 -0.3 0 0 -0.8 0.1 1.6 0 0.3 -0.2 0 0.2 0 -0.1 -0.1 -0.2 0.2 0.1 0 0.2 0.1 0.3 -0.4 0 0 0 0.9 0 0 0 -0.2 0 0 -0.9 -0.8 0.3 -1 -0.8 0.1 0.8 -0.5 -0.4 0 0.8 0.8 -0.5 0.2 -0.2 -1.4 1.3 0.4 -0.4 -0.1 -1.3 1.4 -0.1 -0.5 0.2 0 -0.6 0.8 0 -0.7 0.9 -0.8 -0.4 0.7 0.2 -0.7 -0.1 0.4 -1.7 -0.6 -0.4 NFAT_3PATHWAY__57 0.1 0 0.8 0.2 0.1 0.9 0.1 0 -0.1 1 1.3 1 1.1 1 0.7 1.6 -0.7 2.4 0.1 0.7 -0.7 0 -0.1 0.1 0 1.3 0.7 0 -0.4 -0.4 0.1 0 0.7 0.3 0.1 -0.7 0 0.6 0.1 0.8 -0.3 0.1 0 -0.3 0.1 0 0.1 0.7 -0.3 -0.9 0 -0.8 1.7 -1.8 -0.3 -0.2 0 0 0.8 -0.9 0 -0.1 0 0 0 0 0 0.7 0.1 0 0 0 0 0 0 -1.8 1.1 0.9 -0.7 0.8 0.7 -0.2 -1.2 -0.5 1.7 0.2 -0.9 0 1.1 0.1 -0.1 0.3 -0.5 -0.8 1.1 0 0.1 -0.1 0.9 0.2 -0.1 0 0.4 -1.6 0 1.8 -0.9 -0.1 1.6 0.5 -0.1 0 0.3 -0.3 0 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0 -0.2 1.7 -2 -0.1 -0.8 0.3 0.5 0 0 0.1 -0.4 -0.5 -1.4 0.3 -0.1 -0.1 -0.7 -0.1 0 -1 -0.1 -0.8 -2.4 -0.2 -0.8 0 -0.6 0.5 0 0 0.3 0 -1.5 0.2 0.6 0 0.9 -0.1 1.5 -0.1 1.2 0 -0.3 -0.6 0.6 0 0 0.5 0 0.8 0 0 -1 0 0 0 0.1 0.1 -0.7 0.1 0 -1.5 -0.5 1.5 0 -1.5 0.1 0.4 0.1 -0.9 -4.1 1 0 -2.1 0 0 -1.1 1.3 0.4 -1 -0.3 0 0 -0.3 0.1 0 0 0 0.9 -0.1 -0.7 0.7 -1.5 -0.2 -0.2 0 0.9 -0.4 0 0 -0.5 -1 S1P_META_PATHWAY__21 -0.7 0 -0.2 0 0.1 1.4 -2.5 0.2 0.4 -3.6 -3.7 -3.5 -3.3 -3.7 -1.4 -3.2 2.6 -3 -0.2 -2.6 2.7 0 -1.4 0 0.3 -3.5 -1.1 0 3.2 -0.2 -0.2 -1.6 -0.3 0.2 -1.9 -0.5 -1.4 -0.1 -0.6 -1.5 0.1 0 -0.7 -0.2 -0.2 0 -0.1 -2.2 -0.8 3.3 0.1 -1.1 -1.3 -0.1 -0.3 1.9 0.1 0.1 -1.1 1.1 0 -0.1 0 0 0 -1.6 0 0 0.1 0 -0.1 0.3 0 0 0.4 0.1 -2.3 -0.1 2.2 -0.2 -2.2 -0.4 3.8 0.3 -3.6 -2.5 3.4 0 -2.9 -0.5 0.4 -1.8 1.9 3.9 -3.3 0 0 0 -0.8 0 0 0.2 0 3.3 -0.5 -3.4 3.7 -0.5 -2.2 -0.7 1.3 -2.5 0.2 4 -1.1 -2.1 -3.3 S1P_S1P1_PATHWAY__21 0 0 -0.2 0 0 0 -0.1 0.2 0.4 -3 -3.7 -3 -3.3 -2.9 -1.4 -2 0.1 -1.4 0 -2.6 2 0 -1.4 0 0.3 -1 -1.1 0 0.8 0 -0.2 -1.6 -0.3 0.2 -1.9 0.1 -1.4 -0.1 -0.6 -1.5 0.1 0.1 -0.7 -0.2 -0.2 0 -0.1 -2.2 0 2.4 0 0 -1.3 -0.1 0 0 0.1 0.1 0 0 0 -0.1 0 0 0 0 0 0 0.1 0 -0.1 0.3 0 0 0.4 0.1 -2.3 -0.1 2.2 -0.2 -2.2 0.2 1.6 0 -2.3 -0.1 2.5 0 -1.7 0 0 -1.8 2.9 2.4 -1.7 0 -0.8 0.8 -0.8 0.2 -0.2 0.2 0 2.8 0 -3.4 2.5 -0.5 -1.1 -0.7 1.3 -2.5 0 1.5 -1.1 -3.5 -0.3 S1P_S1P2_PATHWAY__24 -0.4 0.7 -1.9 0 0 1.1 -2.1 0.1 0.2 -1.8 -1.5 -1.7 -1.3 -1.7 -1 -0.3 2 -0.9 -0.1 -1.1 1.6 0.6 -0.9 0 0.1 -0.6 -0.7 -1.6 0.5 0.5 -0.1 0 -0.2 0.1 0 0 -1 0 -1.8 -1.1 0 -0.9 -0.4 -0.1 -0.1 0 -0.1 -0.8 0 0.8 0 -2.9 -0.9 0 0 1.4 0 0 0 0 0 -0.1 0.6 -0.1 0 -1.2 -0.5 2.5 0.1 0 0 0.1 0.2 0.4 -0.2 -0.6 -1.8 -1.8 2.5 -2 -0.8 0.1 1.9 -0.1 -1.8 -2 1.7 0 -1.3 -0.2 0.2 -0.5 0.7 1.2 -0.6 -0.4 0.1 -0.1 -0.5 0.1 -0.1 0.1 0 1.7 -0.2 -1.5 2 -1.8 -0.1 -0.4 -0.1 0 -0.6 1.1 -0.7 -0.7 -2.6 S1P_S1P4_PATHWAY__14 0.1 -0.3 0 -0.1 0 -0.1 -0.4 0.9 1.4 -3.1 -2.5 -2.9 -3 -3 -0.1 -0.6 0.4 -0.9 0 -2.8 1.1 0 -0.1 0 0 0.1 -2.2 -0.2 0 0 -0.9 0 0 1.1 -0.1 0.5 -0.1 -0.5 0 -0.1 0.6 0 0 -1.1 0 -0.4 -0.7 -4.1 0 2.6 0 0.1 -0.8 -0.6 0.1 0.2 0 0.4 0.2 -0.2 0.1 0 0 0 0 -0.2 0 0.2 0.6 0 0 0 -0.1 0 0 0.4 -3.7 0 2.5 0 -3.8 -0.3 1.2 0 -2.1 -0.5 1.7 0 -3.1 -0.3 0.3 -3.1 2.2 1.2 -1.3 0 0 0 0 0.9 0.1 0 -0.1 1.9 0 -1.6 1.5 0.2 -0.8 0 0.1 -0.2 0 0.2 -0.1 -1.1 -1.1 S1P_S1P5_PATHWAY__8 0 0 -0.2 0 0 -0.5 -1.2 0 3 -3.1 -3 -3.4 -3.7 -3.5 -0.7 -1.7 1.2 -0.2 -0.2 -3 2.4 0 -0.6 0 0 -0.5 -0.5 -0.9 0.4 0 -1.9 -0.6 0 0 -0.8 0 -0.7 -1.5 -0.4 -0.7 0 0 0 0 -0.2 0 -1.9 -2.4 -0.4 2.7 0 -0.6 -2 0 0 0.9 0 1.2 0 0 0 0 0 0 0 -0.8 0 0 1.5 0 0 0 0 0 0 1.6 -3.6 -0.1 3 -0.2 -2.4 0.2 2.5 0 -2.5 -1.2 3.1 0 -3 -0.1 0.1 -3 2.3 2.7 -1.5 0 -0.3 0.3 -0.4 0 0 0 0 2.3 0 -3 2.9 -0.3 -0.4 -0.4 0.6 -1.1 0 0.8 -0.6 -1 -2.1 SHP2_PATHWAY__58 0 -1.1 0.7 -0.9 0 0 -0.7 0.1 0.6 -1.8 -2.2 -2.2 -2.1 -1.9 -1 -1.6 0.7 -1.5 -0.2 -1.4 1.2 0 -1 0 0.5 -1.9 -0.7 -0.3 1.5 -0.3 -0.2 -1.1 -0.4 0.2 -1.8 0 -1.1 -1.2 -0.9 -1.2 2 0 -1.4 0 -0.9 -1.4 0.1 -0.9 -0.3 1 0 0.1 -1.4 -0.1 1.2 1.8 0 -0.4 0 0 0 -0.1 0 0.5 -0.9 -1.3 0.1 0.6 0 0 -0.1 0.5 -2.4 0 0.5 1.4 -1.1 0.8 1.5 0.7 -0.9 -0.5 1.6 0.3 -1.5 0 1.3 -0.3 -1.1 -0.7 0.6 -1.2 1.2 2 -2.2 0 -3.5 4 -1.4 -0.3 3.7 0.2 -0.3 1.4 -0.7 -1.2 1.4 1.2 -1.9 -0.2 0.8 -2.5 0 1.2 -0.7 -1.9 -1.1 SMAD2_3NUCLEARPATHWAY__82 0.3 0 -0.1 0.3 0.2 1.2 0 -0.1 0 0.1 0.1 0.1 0.1 0.1 0.6 0.5 0 0.1 0.1 0.2 0 -0.2 0.2 0 0 0.6 0 0 0 0.1 0 0.1 0 -0.1 0.2 0.1 0 0 0 -0.1 0 -0.3 0.2 0.7 0 0.1 0 0 0 -0.1 0 -0.2 0.1 -0.1 0 0.2 -0.1 0 0 0 1.6 -0.2 -0.2 1.1 0.6 -0.1 -0.1 0.6 -0.5 0 0 0 1.1 0 -1.1 -0.1 0.1 -0.2 0 -0.1 0 0 -0.1 -0.1 0.1 0.4 0 -0.1 0.3 0 0 0 -0.1 0 0 -0.1 0.1 -0.1 0 -0.2 -0.2 0 0.7 -0.1 0 0.1 -0.1 0 0.7 -0.3 -0.1 0 0.7 0 0 0.1 -0.1 SMAD2_3PATHWAY__20 0 1.1 -1.3 0 0.1 0 0 -0.9 -0.1 0.3 0.1 0.3 0.3 0.3 0 0.5 0 1.4 -0.3 0.5 0.1 -1.4 0 0 0 0 0 0 0 0 0 0 0 0 0.2 0.1 0 0 0 1.3 -0.3 0.2 0 0 0 -0.1 -0.2 0.5 0.6 -0.6 0.1 0 0 2.5 0 0 -0.9 -1.1 0 0 -0.4 3.3 -1.5 -0.3 0 0 -1.3 0 -0.4 -0.2 0 0 0.5 0 -0.5 0 0.7 -1.2 0 -1.3 0.5 -0.1 -0.1 -0.4 1.1 -0.1 -0.4 0 0.4 -0.1 0.1 0.3 -0.6 0 0 -0.9 0.1 -0.1 0.1 -2.4 -0.2 0 0 -0.7 -0.6 0.8 -0.1 -0.6 0.2 0 -0.1 0 0.3 0 0 0 0 SYNDECAN_1_PATHWAY__46 0 -2.6 -0.6 0 0 0 -1.8 0 1.7 -2.3 -1.9 -2.2 -2.1 -2.4 -0.6 -2.6 1.8 -1.9 0 -1.2 2.5 0 -0.5 0 1.7 -1.7 -1.8 0 4.2 0 0 -0.5 0.1 0 -3.5 0.2 -0.6 -2.4 -0.8 -2.6 0.4 0 0 0 0 -0.2 -0.6 -2.1 0 1.4 0.5 -0.4 -4.2 0.1 0.6 0.1 0 4.2 0 0 0.4 -0.5 0 0 3.9 -3.7 0.3 -0.1 0 0.1 -0.7 1.8 0 0 0 0 -2.4 -0.5 1.8 -0.7 -2.1 0.1 2.5 0 -3.6 -0.2 2.8 -0.1 -1.5 0.1 -0.1 -1.6 1.8 3.1 -3.7 1.1 -0.1 0.1 -2.8 0.8 0 1.3 0 3.5 0 -4.2 3.7 -0.1 -0.7 -4.2 4.2 -3.9 0 2.3 -1.8 -3.5 -2.3 SYNDECAN_2_PATHWAY__33 -0.1 -1.2 -0.1 0 -0.1 -0.9 0.6 0 0 0.8 0.7 0.8 0.8 0.8 -0.2 0 -0.5 0.9 -0.3 0.8 -0.8 -0.1 0 0.2 0 0.3 0.5 0.6 -0.1 0.1 0.1 0.1 0 -0.1 -0.3 0 0.1 0.1 0 0.1 0 0 0.1 0 0 0.1 0.2 0.9 0.1 -0.9 0 0.3 -0.2 0 0.1 -0.9 -0.1 0.9 0 0 0.1 0 -0.1 0.1 0.2 0.5 0 -0.5 -0.4 0 0 0 0 -0.2 0 -0.1 1.3 -0.1 -0.4 -0.1 0.8 0.1 -0.3 -0.4 0.3 0 -0.1 0 0.6 0.1 -0.1 0.5 -0.5 -0.3 0.4 -0.1 0 0 -0.1 0 0 0 0 -0.3 0.2 0.4 0.6 0 0 0.6 0.1 -0.6 -0.1 0.3 1.1 0.1 1.7 SYNDECAN_3_PATHWAY__17 0 -0.2 0 0 0 -0.1 -0.3 0 1.2 -1 -1.3 -0.9 -1.1 -1 0 -0.5 0.3 0 0.9 -1.3 -1.5 1.6 3.1 0 0 0 -0.1 -0.1 -1.8 0 0 0 -1 0.9 -0.1 0.3 -0.1 -0.3 0 -0.1 0 0 0 0 0 -0.3 -0.6 -1.1 1.1 1.1 0 0.1 -0.7 0.2 -0.8 0.2 0.4 0.3 -1.8 1.8 0 -0.5 1.6 -0.8 0 -0.1 0 0 0 0.2 0 0 -0.1 1.4 0 0 -1.2 0 0.7 0 -1.1 1.7 -1 0.8 -1.1 0 1.5 0 -1.5 1.6 -1.6 -0.4 0.9 -1.6 0.8 0.9 0 0 0 0.7 0 0 -0.1 1 0 -0.6 1.3 0 -0.2 2.6 0 -0.1 0 -1.7 0.3 -0.1 1.1 SYNDECAN_4_PATHWAY__32 -0.2 -1.6 -0.3 0 -0.1 -0.1 -1.3 0 0 -0.9 -0.8 -0.9 -1.1 -0.9 -0.3 -2.1 1.2 -0.3 -0.5 -0.5 3 -0.1 -0.3 0 0 -0.2 -0.2 0 1.5 0.1 0 -0.3 0 0 -0.6 -0.1 -0.4 -1.7 -0.1 -0.4 0 0 0 0 0 0.1 0 -0.3 0.1 0.3 0 0 -2.6 0 0.3 0.8 0 1.3 -0.3 0.3 0.2 0 -0.1 0.1 0.4 -0.6 -0.1 -0.7 0 0 0 0 0.1 -0.3 0 0 -0.4 -0.2 1 -0.3 -0.3 0.2 1.1 0 -2.4 0 3.1 0.9 -0.1 -0.4 0.4 -0.1 0.8 2.3 -2.5 0 -0.1 0.1 -1.5 0 0 0 0 2.6 0 -2.8 4 -1 -1 -3.1 2.3 -0.9 -0.2 2.6 -1.9 -3.9 -0.6 SYNDECAN_PATHWAY__4 0 0 0 0 0 0 0 0 0 -0.3 -0.3 -0.3 -0.3 -0.3 0 -0.3 0 0 0 -0.6 1.4 0 0 0 0 0 0 0 -1.4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.5 0 0 -0.8 0 0 2.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -0.6 0 0.4 0 0 0 0.3 0 -1.4 0 1.8 0 0 0 0 0 0 -0.4 -0.3 0 0 0 0 0 0 0 0 1.4 0 -0.4 2.2 0 -0.3 0 0 0 0 1.8 -1.6 -0.4 -1 TAP63PATHWAY__54 0 0 2 0 0 -0.1 0.1 0 -0.1 0.6 0.7 0.6 0.7 0.6 0.2 0.1 -0.1 0.2 0.6 1 -1.5 1.7 0.7 0 0.8 0.2 0.9 0 -2.1 0 0.1 0 3.5 0 0.2 0 4.1 -0.1 0.7 0 0.1 0 0 0 -2.3 0 0.2 0.5 0 -0.5 0.1 0 0.7 0 -0.4 -0.4 0.1 0 0 0 0 -0.1 1.7 0 0 0 0.1 -2.9 0.1 1 0 0.9 0 1.4 0 0 0.4 2.2 -1.4 1.9 0.5 -0.8 -0.7 0.5 0 1.8 -0.2 0 0.8 0.6 -0.6 0.5 -0.3 -1.1 0.4 0.5 0.1 -0.1 0 0.3 -0.2 0.5 0 -0.2 0 0.2 -0.9 0 1.4 0.7 -0.1 0 0.5 -0.5 0 0 0.8 TCPTP_PATHWAY__43 0 0 1.3 -0.8 0 -0.3 0.1 0 2.2 -0.1 -0.3 -0.1 -0.2 -0.1 0 -0.7 -0.1 -0.3 0.1 -0.3 0.3 -0.6 0.1 1.3 0 -2.2 0.1 -0.1 -0.4 0 0 -0.9 0 0 0 0 0 0 0.2 0 0.7 0 0 -1.9 0 0 0 -0.2 -0.3 0.1 0 0 -0.3 0 1 0.1 0 -0.4 0 0 0 0.3 -0.6 0 0 1.8 -0.4 0.1 -0.1 0 -1.2 0 -1.9 0 2 0.5 0 1.3 -0.1 1.2 -0.2 0.2 -0.4 -0.7 -0.2 -0.4 0.9 -2.5 -0.4 0.2 -0.2 0 0.1 0.8 -0.5 0 -3.7 3.9 0 -1.8 3.8 0 -2 0.8 -2.7 -0.4 0.6 1.3 -0.7 -0.2 0 -0.1 0 -0.2 0 -1.7 0.1 TCRCALCIUMPATHWAY__32 0.3 -1.6 1.4 0.1 -0.1 1.6 0 -0.1 0 0 0 0 0 0 -0.3 -0.3 0 -0.3 -1.7 -0.1 0.1 0 -0.3 -1.1 -0.6 -0.2 0 0 0.1 0.1 0 0 1.1 -0.2 0 -0.1 -0.4 0 1.1 0.2 0 0 -0.1 0 -0.5 0.1 0.4 0.2 -1.7 -0.1 0 -1.9 0.1 -2.1 0 0 -0.2 0 1.3 -1.4 0.2 -2.2 0 2 0 -0.6 0 1.2 0 0 0 -0.6 0.1 0 0 -0.2 0.1 1.4 -0.2 1.4 0.2 -1.7 0 0 0 0.1 0 -0.1 0 -1.2 1.2 0.2 -0.1 0.2 0 -0.1 0 0 0 0 0 -0.4 0.1 0 0.4 -0.1 0.1 1.9 -1 -0.1 0.3 0 -0.2 0 0 -0.2 -0.6 TCRJNKPATHWAY__14 0.1 -0.3 0.9 -0.1 0 1 0 0 0 0 0 0 0 0 -0.1 -1.5 0.4 -0.9 -1 0 0 0 -0.1 0.1 0 0 0 0.2 0 0 0.1 0 0 0 0 0.5 0.1 0 0.7 0.1 0.6 0 0 0 -1 0 0.1 0.1 -2.2 0.3 0 0.1 0 0 0.1 0.2 0 0.4 0.2 -0.2 0.1 0 0 0 0 -0.2 0 0.2 -1.4 -0.9 0 0 -0.1 0 0 0 0.1 1 -0.1 0.9 0.1 -2.3 0.1 0 -0.1 0 0 0 0.2 -1.4 1.4 0 0 0.1 -0.1 0 0 0 0 -0.1 0.1 0 0 0.1 0 -0.1 0 3 -2.1 0 0 -0.2 1 0.2 -0.1 -0.2 0 TCRRASPATHWAY__14 0.1 -0.3 -0.8 -0.1 0 -0.1 0 0 -0.7 0.3 0.1 0.3 0.3 0.3 -0.1 -0.1 0 0.7 0 0.3 0.1 0 -0.1 0.1 0 0.1 0 0 -0.1 0 0.1 0 0.2 0 0 0.5 0.1 0 0 0.1 0 0.8 0 0 0 -0.4 0.1 0.5 0 -0.3 0.6 0.1 0 -0.6 0.1 0 0 0 0.2 -0.2 0 0.4 0 0 0 0.2 0 0.2 0 0.3 0 0 1.2 0 -1.3 0 0.7 -0.7 -0.1 -0.8 0.5 -0.3 0.1 0 0.1 0 0 0 0.2 -0.3 0.3 0.2 -0.6 0.1 0 0 0.6 -0.6 0.3 0.9 -0.7 0 -0.1 0 0 0 0 -1.5 -0.3 0.3 0.1 0 0 0 0.4 -0.2 0 TCR_PATHWAY__66 -0.5 -2.8 4 -0.4 -0.7 -0.1 -0.4 2.1 0.2 -0.1 -0.1 -0.1 0 -0.1 -2 -3.9 0.4 -2.6 -3.9 -0.4 0 -0.2 -3.9 0 0.1 -0.2 0 0.2 2.2 -2.8 0.6 -2.4 -0.2 -4 0 -0.3 0 0.2 4 0.3 3.9 -1.6 0 -2.8 -3.1 0 0.8 -0.2 -4 0.5 0 0 0 0.2 2.5 0 0 -0.1 0 0 0 0 -0.2 -0.1 -0.4 0 0 0.2 0 -2.1 0 0.2 -0.1 0 0.2 0 -0.1 4 -0.1 4 -0.2 -4 0.4 1.9 -0.6 0.1 0 -0.1 -0.6 -4 4 -0.1 0 1 -1.1 0 -0.9 0.9 -2.1 -0.1 0.6 0.1 -0.1 0 0 -0.1 0 4 -4 -0.1 0 -0.1 0.1 0.1 -0.3 -1.3 0 TELOMERASEPATHWAY__68 3 0 0 2.9 1 1.6 2.2 -0.5 -1.2 2.6 2.7 2.6 2.5 2.6 2.8 3.9 -2.1 3.9 1.1 2.5 -1.7 -0.1 1.1 0.6 0 1.9 1.8 3 -2.1 0 0.4 0.6 1.8 -0.8 3.9 0 1.2 2.8 0.5 1.2 -1.9 0 1 0 1.5 0 2.2 1.5 0.2 -1.3 0 -0.2 3.9 -0.9 0 -0.4 -0.6 -0.9 2 -2.1 0 0 -0.1 0 -0.3 1.1 -0.1 0.1 -1.8 0 0 0 0 0.4 -2.4 0 2.8 0.1 -2.8 0 1.5 0.7 -3.4 -0.7 3.8 0.5 -3.9 0 2.1 0.8 -0.7 1.1 -1.4 -2 2.8 -0.6 0 0 0.3 -0.1 0 0 1.7 -3.9 -0.2 3.9 -3.4 0 3.9 0 -0.9 0 2.1 -0.5 0 3.6 0.1 TGFBRPATHWAY__55 0.1 2.4 -0.3 0 0.2 -0.6 0.2 -1.8 -0.2 -0.2 -0.1 -0.2 -0.2 -0.2 0 0 -0.2 0.2 0.7 -0.6 0.6 -1.4 0 0.2 0 0 -0.1 -0.7 0 2.3 0.2 -0.1 -0.8 0.6 -0.4 1.9 -0.3 0.1 -0.4 -1.8 0 0.2 -1.9 0 0.2 0 -0.2 -0.9 1 0 0.1 0.3 0.1 -0.1 0.1 0 0 0.1 0 0 1.4 -0.2 -1.4 2.8 0 0 -1.1 0 -1 -0.4 -0.2 0 0 0 0 0 -0.5 -0.2 0.7 -0.3 -0.8 1.1 0.1 -0.9 0.1 -0.1 0.2 -0.8 -0.3 1.2 -1.2 -0.4 0.7 0.1 -0.1 0.5 0.1 -0.1 0 -0.6 -0.2 0 0 0.2 -1.3 -0.2 0.3 -0.3 0 -0.5 0 0 0 -0.5 -0.1 0.1 -0.1 THROMBIN_PAR1_PATHWAY__43 0.7 -0.2 -0.9 0 0.8 1.2 -2.1 1.2 0 -2.7 -2.9 -2.6 -3.1 -2.7 -2.9 -0.6 2 -1.1 -0.4 -2.5 2.4 0 0 -0.3 0 -2 -2.1 -1.7 1.6 0 -1.1 -3.3 -1.7 1.6 -1.3 0.4 -2.6 -0.4 -2.5 -1 0.6 0 0 -1.7 -0.4 -0.3 -0.8 -1.8 -0.2 3.3 0.8 -0.6 -1 0.1 0 1.5 0.6 0.3 0 0 0 -0.7 0 0.4 0 -1.1 0.4 -0.1 0.5 0.2 0 0 -1.8 0 1.9 0.4 -2 -1.6 2.6 -0.9 -1.7 0.1 2.4 -0.6 -1.7 -2.1 2.1 0.3 -1.8 -0.2 0.2 -2 2.2 1.7 -1.3 0 -1.8 1.8 -0.3 0 0.9 0 0 2.1 0 -1.7 2.3 -2.4 -0.9 -0.2 0.7 -0.1 0 2.7 -2.3 -1.6 -1.5 THROMBIN_PAR4_PATHWAY__15 -1.2 -0.2 -0.6 0 0.5 2.4 -0.3 0.7 0 -1 -0.5 -0.9 -0.4 -1 -0.1 -0.5 0.3 -0.7 0 -0.3 0.3 0 -0.1 0 0 -2.1 -0.1 -0.1 0 0 -0.7 0 0 0.9 -0.1 0 -2.5 0 -1.4 -0.1 0.4 0 -1.7 -0.9 -0.8 -0.3 0 -0.2 0 1.1 0 0.1 0 -0.5 0 0.2 0 0 0.1 -0.1 0 -0.5 0 0 0 -0.1 0 0.1 0 0.2 0 0 -0.1 0 1.1 0.3 -0.2 -0.5 0.1 -0.6 -0.2 -0.2 1 -1.1 -0.4 -0.4 0.5 0 -0.4 -0.2 0.2 -0.4 0.9 0.3 -0.4 0 0 0 0 -0.1 0 0 -0.1 0.4 0 -0.6 0.5 -1.3 -1.3 0.2 0 -0.1 -1.7 0.1 -0.1 -0.1 -0.9 THROMBIN_PATHWAY__1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -2.6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.5 0 0 1.9 0 0 0 0 0 0 0 2.2 -2.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TNFPATHWAY__46 0.4 -0.1 0.2 0 0.5 -0.2 0 0.8 0 0.1 0.1 0.1 0.1 0.1 0 -0.1 0 0 -0.2 0.1 -0.2 0 -0.5 0.8 0 0 0.5 0.1 -0.2 0 0.6 0 0.1 0 0 0 0.3 0.2 0.6 0 0.4 0.7 0 0 0.1 -0.2 0.7 0.3 -0.1 -0.1 0.5 0 0.2 1.5 0 0.1 0.4 -1.6 0.1 -0.1 0.4 -0.5 0 0.2 0 0 0 -0.1 -0.4 0.1 0 0 0 0 0 0 0.5 0.2 -0.7 0.2 0.3 -0.3 -0.1 0 0.1 1.1 0 -1.7 0.3 -0.4 0.4 0.1 -0.1 0 0 0 0 0 0.1 0 0 0 0 0 0 -0.1 -0.1 1 -0.1 0.1 -0.5 0 0 -0.1 0.2 0.2 0 TOLL_ENDOGENOUS_PATHWAY__26 -3.9 -2.7 0 -0.9 -0.5 -3.2 0.2 3.9 0 0.7 0.6 0.8 0.3 0.8 -1 -1.5 -0.2 0.1 -1.1 1 -0.3 0 0 -1.6 -1.2 0 0.2 0 0.5 0 1 0.5 -0.2 0 0.1 -0.2 0 0.6 0.1 0 0 0 0 -0.1 -0.1 0 0 1.4 -0.4 -1.1 0 3.3 -0.9 1.8 1 -2.2 -0.5 -0.5 0 0 0 0 0 0 0 0 0 -1.1 -0.1 -0.1 0.9 -1.1 0.2 -0.9 0.2 -0.6 0.9 0 -0.2 0 1.4 -0.8 -0.2 0.2 0.1 0 -0.2 0 0.8 -1 1 0.6 -0.8 0.2 -0.2 0.1 -0.4 0.4 -0.5 0.1 -0.1 -0.9 -1.8 -0.3 0.9 0 -0.1 0.5 -1.2 0 0.8 -1.9 -0.6 0 0 0 3.2 TRAIL_PATHWAY__28 -0.2 0 0.6 0.1 0 -0.2 0.1 0 0.1 0.8 1.3 0.8 0.9 0.8 0 0.1 -0.1 0.4 0.1 1.4 -0.8 -0.2 0 0 0 0.6 2.6 0 -0.2 0 3.1 0.2 1.4 0 0 -0.1 2.4 0.3 1.3 0.4 0 -0.5 -0.1 0 -0.6 0.2 3.4 1.5 -0.1 -0.6 0 0 1.8 0 0.5 -0.1 -0.2 -2.2 1.6 -1.6 -0.1 0 -0.2 0.2 -0.1 0 -0.2 0 -1 0 0 0 0.1 -0.5 0.1 -0.3 2 0.6 -1.5 0.6 1.5 -0.4 -0.7 0.1 0.8 0.1 -0.4 -0.1 1.2 -0.6 0.5 1.9 -1.8 -0.2 0.3 -0.2 0 0 1.6 0 0 0 0.1 -0.1 0.5 0.1 -0.8 0.6 0 0 0 0.7 -0.3 -0.1 0 0.2 0.1 TRKRPATHWAY__62 0 0 -1 0 0 0 -0.6 -1 0.4 -1.6 -1.4 -1.6 -1.5 -1.6 0 -0.3 0.6 -0.1 0.3 -1.9 0.4 0 0.3 0 0.3 0 -1.8 -1.9 0.2 0 -0.1 -0.8 -0.3 0.1 -0.1 0 -0.9 -1 -1.8 -1 -0.1 0 -1.1 -0.1 0.1 -1.1 -1.7 -1.8 -0.2 2.1 0 0 -0.5 0 -0.2 0.2 0 0 0 0 0.6 0 0 0.3 0 -0.1 0.1 0.4 -0.3 0 0 0.4 -0.2 0 0.3 0 -2 -1.6 2.3 -1 -1.8 0.6 0.6 -0.3 -0.5 0 0.4 -0.2 -2.2 0.1 -0.1 -1.7 2.1 0.6 -0.7 0 -1.3 1.3 -0.2 -1.8 0.9 0.1 0 0.3 -0.6 -0.4 0.4 -1.6 -0.1 0.3 0 -0.2 0.1 0.1 0 0 -0.2 TXA2PATHWAY__57 -0.8 -1.2 0.8 -1.1 -1.2 -0.3 -0.8 3.2 0.7 -1.5 -1.8 -1.5 -1.4 -1.6 -1.1 -4.1 0.8 -2.7 -2.1 -1.5 0.6 0 -2.9 0 0.5 -3.3 -0.7 -0.4 3.4 -0.4 -0.2 -1.2 -0.5 0 -0.2 -0.7 -1.2 0 -1 -0.1 2.1 0.1 -1.4 -3.5 -1.9 0 -0.1 -1 -1.8 3.4 0 -0.8 -0.7 0 -0.3 0.4 0 0 0 0 0 -0.1 0 0 0 -0.2 0.1 0 0.1 -0.2 -0.1 0.6 -0.4 0 0.5 1.6 -1.8 0.9 0.8 0.8 -1 -1 2.2 0.3 -3.7 0 0.8 0 -1.8 -1.4 1.4 -0.7 0.8 2.5 -2.9 0.3 -0.3 0.3 -2.9 0 0.1 0.3 -0.3 1.5 0 -1.8 1 3 -4.1 0.5 0.9 -0.4 0 1.2 -0.1 -2.9 -1.2 UPA_UPAR_PATHWAY__42 -2 -0.3 -0.3 -3.1 0 -3.7 -0.3 0 0 -1.8 -2 -1.8 -2.2 -1.9 0 -2.6 0.3 -0.4 0.7 -2.7 1.6 0 0.2 -0.4 2.5 -2.3 -0.7 0.2 0.4 0 -1.2 -1.1 -1.9 0 -3.9 0 -2.9 -0.5 -0.2 -1.2 0 0 0 0 0 -0.5 -1 -2 2 0.6 0 2.8 -2.3 0.2 0 -1.6 0 0.4 0 0.1 0 -0.9 0 0 0 0.1 0.5 -0.1 0 0.2 -1.3 2.5 -0.1 -4.3 2.2 0.6 -1.5 -0.2 1.7 -0.3 -1.9 0.7 1.5 0 -2 0.3 1.3 0.3 -2 0.8 -0.8 -2.2 2.4 2 -2.1 1.7 -2.1 2.1 -1.8 -0.1 1.1 2.1 -2.1 1.3 0.1 -1.4 2.5 0.1 -1.1 -0.3 3.2 -2.2 0 1.2 -0.7 -1.8 2.1 VEGFR1_2_PATHWAY__72 0 0 -0.8 -0.1 0 0 0.1 -0.3 0 -0.4 -0.3 -0.4 -0.3 -0.4 0 0.1 -0.1 0.1 0.2 -0.4 0.3 -0.1 0.8 0.3 0 -0.1 -0.1 -0.8 0 0 0 0 -0.1 0 -0.5 -0.1 -1.2 0 -0.2 0 0 0 -0.3 0 0.1 -0.3 0 -0.5 0.1 0.2 0 0 0 0.9 0 -0.2 0.6 -0.6 -0.7 0.7 0.1 0 -0.1 0.7 0 0 -0.7 0 0 0.1 0 0 -0.8 0 0.1 0.3 -0.3 -0.7 0.3 -0.8 -0.5 0.9 0 -1.3 0.1 -0.2 0.1 -0.5 -0.6 0.5 -0.5 -0.7 0.7 -0.1 0.1 -0.3 -0.3 0.3 0.1 -0.7 0.2 0 0 0.1 -0.1 -0.2 0.1 -1.6 0 0.1 -0.6 1.4 -0.5 -0.3 0.2 -0.1 0 VEGFR1_PATHWAY__29 -0.2 0 -0.3 -0.3 0 0 0 -0.1 0.1 -1.1 -0.9 -1.1 -1.3 -1.1 -0.4 -0.3 0 -0.4 -0.6 -0.6 2.1 -0.2 0 0 0 -0.2 -0.3 0 0.1 0 0 -0.3 -0.1 0 -0.7 -0.1 -0.5 0 -0.1 -0.5 0 0 -0.1 0 0 0 0 -0.4 -0.1 1.1 -1.3 -0.4 -0.4 0 0 0.8 -0.2 -0.2 -0.4 0.4 0.3 0 -0.2 0.2 0 0 -0.1 0 0 0 0 0 0 -0.4 0 2.1 -0.5 -0.3 0.6 -0.3 -0.4 -0.1 0.6 -0.8 -1.1 0 1.4 1 -0.8 -0.1 0.1 -0.2 0.3 1.1 -1.3 0 -1.8 1.9 -0.2 -0.8 0.4 0 0.1 1.6 0 -1.6 1.6 -1.1 -0.1 -0.1 0.3 -1 -0.2 0.6 -0.3 -0.2 -0.7 VEGF_VEGFR_PATHWAY__10 0 -0.9 -0.1 -0.2 0 0 0.1 0 0 -1.8 -2.2 -1.8 -2 -1.8 -0.3 -4 -0.1 -1.6 0.1 -2.4 1.8 0 0 0 2.4 -0.2 -0.3 0 0.2 0 0 -0.2 -1.9 0 -0.4 0 -0.4 0 -0.2 -0.4 0 0 0 0 0.1 0 -1.4 -0.7 -0.1 2.1 0 -0.3 -1.4 0 0 0.6 1.2 0.8 0 0 0 0 0 0 0 -0.5 0 0 1.1 0.7 -1.6 2.3 0 0 0 1.1 -0.7 -0.1 1.4 -0.1 -0.7 0.1 1 0 -4.1 0 2.4 -0.1 -2.4 0.1 -0.1 -1 1.8 1.9 -2 0 -0.1 0.1 -2.9 0 0.3 1.9 -0.5 2.8 0 -3.6 2.3 0 -0.7 -0.1 0.3 -4.2 0 0.5 -0.3 -1.9 -1.7 WNT_CANONICAL_PATHWAY__20 1.7 1.3 -1.5 0 0.2 0.5 0.7 0 -0.2 0.1 0.1 0.1 0.1 0.1 0.7 2.5 -0.6 0.2 0.5 0.1 -0.3 0 0.1 2.3 -1.9 0 0 0 0 0 0 0 0.1 0 0 -0.7 0 0 0 0 -0.4 0.2 0 0 0.7 -0.1 0 0 0 -0.1 0.1 -1.4 0 2.6 -0.4 0.1 0.1 -1.3 -1.3 1.3 -0.5 0.1 0 -0.4 0 0 -1.5 0 -0.6 0.1 1.6 -2 0.6 0.9 -0.6 0 0.2 -1.4 0 -1.4 0 1.1 -0.6 -0.5 2.2 -0.2 0.1 0 0.1 1.1 -1.2 0 0 -2 2.2 -1 0.2 -0.2 0.1 0 0 -1.7 0 -0.1 0 0.1 -0.5 -0.8 1.7 2.1 -0.2 0 0.4 -1 0.1 0 0.6 WNT_NONCANONICAL_PATHWAY__32 0.2 0.2 -0.9 0 -0.1 1.4 -1 -0.1 0 -0.8 -0.6 -0.7 -0.4 -0.7 0.7 0.6 1 0.1 1.4 -1.1 1.1 0 0.7 0.2 -0.4 0.3 -0.2 -0.6 -0.1 0.1 0.2 -0.1 0 0 0 0 -0.3 0.1 -0.1 -0.3 0 -0.2 0 0.4 0.6 0 0.3 -1.5 0 0.8 0 -1.6 -2.3 0 0.2 0.6 -0.1 1.1 -0.2 0.2 0.1 -2 0 1.7 0.3 -0.4 0 0 -0.5 0 0.3 -0.4 -0.6 0.1 0 0 -0.9 -0.8 0.8 -1 -1.5 0.7 0.4 -0.5 -0.8 0 1.5 0 0.7 0.8 -0.8 -1.4 1.3 -0.9 0.5 -0.1 0 0 -0.1 0 0.2 -0.3 0.1 0.8 0 -0.7 1.3 -0.8 1.4 -1 0.2 0 -0.1 -1.1 -0.1 1.1 -1.6 WNT_SIGNALING_PATHWAY__28 0 0.4 -1.5 0 -0.2 0.1 -1.6 -0.2 0.1 -2.5 -2.6 -2.5 -2.2 -2.6 0.2 -1.9 1.6 -0.6 2 -2.8 1.8 0.4 1.2 0 0.1 -0.3 -2.4 -1.2 0.2 0.3 -0.1 -0.5 -0.1 0 -0.9 0 -0.7 -2.2 -3.2 -3.4 0 -0.6 0.5 0 0.1 0 -2.9 -2.9 0 3.5 0 -0.5 -4 0 -0.1 1.1 -0.3 1.6 -0.5 0.5 -0.1 0 0.4 -0.1 0.7 -0.8 1.5 -0.9 0 0 0 0.1 0 0 0.1 0 -3.3 -1.4 4.3 -1.6 -3 2.8 1.4 0.1 -2.8 0 2.1 0 -3 2.1 -2 -3.2 3.6 1.4 -1.6 -0.2 -0.2 0.2 -1.9 0 0.6 0 0 2.5 -0.1 -2.5 1.9 -1.3 -0.2 -1.7 0.5 0 -0.3 0.8 -0.4 -1.1 -2.2